Water maze versus radial maze: differential performance of rats in a spatial delayed match-to-position task and response to scopolamine. 2002

Brandi K Ormerod, and Richard J Beninger
Department of Psychology, Queen's University, Kingston, Canada K7L 3N6. brandik@interchange.ubc.ca

Studies rarely assess treatment effects across tasks; the present experiments addressed this issue. In Experiments 1 and 2, rats (n=12) were trained and then tested with variable delays on a spatial match-to-position task sequentially in the water and radial mazes (in counterbalanced order). Experiment 1 compared the effect of 0-, 60- and 1440-min delays on performance in both mazes. Rats required fewer (P<0.05) mean (+/-S.E.M.) sessions to reach criterion performance in the water (11.0+/-1.0) versus radial maze (19.3+/-2.2). In test sessions, performance was impaired delay-dependently when scores were averaged across the two tasks (P<0.05) but no significant effect of task or task x delay interaction was found. In the second experiment, the same rats were retrained and tested with 0-, 1-, 3- and 5-min delays in both mazes and testing followed the administration of scopolamine (0, 0.1, 0.4 and 0.8 mg/kg). The mean (+/-S.E.M.) number of acquisition sessions was similar in the radial (6.33+/-0.34) and water maze (6.08+/-0.46). On the sample portion of trials, performance was impaired at the 0.8 mg/kg dose of scopolamine (P<0.02) in the radial maze only. On the recognition portion of trials in the radial maze, the 0.4 and 0.8 mg/kg doses of scopolamine impaired performance whereas in the water maze task the 0.8 mg/kg dose impaired performance. The pattern of results may reflect different natural tendencies of rats to alternate (win-shift) versus not alternate (win-stay) in dry land versus swim tasks.

UI MeSH Term Description Entries
D008297 Male Males
D008568 Memory Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
D011597 Psychomotor Performance The coordination of a sensory or ideational (cognitive) process and a motor activity. Perceptual Motor Performance,Sensory Motor Performance,Visual Motor Coordination,Coordination, Visual Motor,Coordinations, Visual Motor,Motor Coordination, Visual,Motor Coordinations, Visual,Motor Performance, Perceptual,Motor Performance, Sensory,Motor Performances, Perceptual,Motor Performances, Sensory,Perceptual Motor Performances,Performance, Perceptual Motor,Performance, Psychomotor,Performance, Sensory Motor,Performances, Perceptual Motor,Performances, Psychomotor,Performances, Sensory Motor,Psychomotor Performances,Sensory Motor Performances,Visual Motor Coordinations
D005502 Food Substances taken in by the body to provide nourishment. Foods
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012201 Reward An object or a situation that can serve to reinforce a response, to satisfy a motive, or to afford pleasure. Rewards
D012601 Scopolamine An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Its many uses include an anesthetic premedication, the treatment of URINARY INCONTINENCE and MOTION SICKNESS, an antispasmodic, and a mydriatic and cycloplegic. Hyoscine,Scopolamine Hydrobromide,Boro-Scopol,Isopto Hyoscine,Kwells,Scoburen,Scopace,Scopoderm TTS,Scopolamine Cooper,Transderm Scop,Transderm-V,Travacalm HO,Vorigeno,Boro Scopol,Transderm V
D013028 Space Perception The awareness of the spatial properties of objects; includes physical space. Perception, Space,Perceptions, Space,Space Perceptions
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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