-transparent.png){kind=logo}
OBJECTIVE To investigate central nervous system (CNS) involvements in systemic lupus erythematosus (SLE) so as to enhance our knowledge in diagnosing and treating CNS involvement of SLE. METHODS The clinical data of 171 in patients with CNS involvement of SLE in our hospital were retrospectively reviewed. RESULTS The mean SLE disease duration at onset of CNS involvement was (2.21 +/- 1.87) years and in 163 (95.3%) it was associated with active disease. Cerebral spinal fluid abnormality was seen in 91.4% (138/151) of the patients with CNS involvement of SLE. Among them protein elevation was found in 113, pressure elevation in 69, white cell elevation in 51 and glucose reduction in 6. For the evaluation of CNS involvement of SLE, the sensitivity of cranial CT and MRI was 77.4% and 81.4% respectively (P > 0.50). The positive rate of antiribosomal P in patients with diffuse CNS involvement of SLE was significantly higher than that in patients without CNS involvement (P < 0.01). On the contrary, the positive rate of ACL in focal CNS involvement of SLE was significantly higher than that in diffuse type or in patients without CNS involvement (P < 0.01). The total mortality rate in 171 patients with CNS involvement of SLE was 18.7%. The Mortality rate in the period of 1993 to 1998 (4.0%, 3/75) was significantly lower than that of 1980 to 1992 (30.2%, 29/96), P < 0.01. 24 SLE patients with CNS involvement received intrathecal dexamethasone and methotrexate, 22 cases (91.7%) improved considerably. CONCLUSIONS CNS involvement occurs in the early stage of SLE, most of the cases are associated with active disease. Cerebral spinal fluid analysis is the most essential test and cranial imaging serves as a supplementary approach, of which CT is preferred. ACL is associated with focal CNS involvement of SLE while antiribosomal P with diffuse CNS involvement of SLE, suggesting there might be different mechanisms in CNS involvement of SLE. Intrathecal therapy is an useful alternative for patients with CNS involvement of SLE refractory to conventional therapy.
X Zhang, and
Y Dong, and
F Tang, and
H Li, and
F Zhang
March 1990,
Deutsche medizinische Wochenschrift (1946),
X Zhang, and
Y Dong, and
F Tang, and
H Li, and
F Zhang
January 1984,
Revue neurologique,
X Zhang, and
Y Dong, and
F Tang, and
H Li, and
F Zhang
December 2000,
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology,
X Zhang, and
Y Dong, and
F Tang, and
H Li, and
F Zhang
June 1992,
The Psychiatric clinics of North America,
X Zhang, and
Y Dong, and
F Tang, and
H Li, and
F Zhang
November 1981,
Arthritis and rheumatism,
X Zhang, and
Y Dong, and
F Tang, and
H Li, and
F Zhang
August 2007,
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases,
X Zhang, and
Y Dong, and
F Tang, and
H Li, and
F Zhang
June 1989,
Klinicheskaia meditsina,
X Zhang, and
Y Dong, and
F Tang, and
H Li, and
F Zhang
April 1982,
Minnesota medicine,
X Zhang, and
Y Dong, and
F Tang, and
H Li, and
F Zhang
April 1989,
Harefuah,
X Zhang, and
Y Dong, and
F Tang, and
H Li, and
F Zhang
December 1988,
Israel journal of medical sciences,
