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The frequency of PC allele for acid phosphatase in fourteen Sardinian villages correlates positively with the altitude and negatively with past malarial morbidity and GdMed prevalence. The susceptibility towards hemolytic favism in Sardinian males with G6PD deficiency is dependent on the erythrocyte acid phosphatase and thalassemia phenotypes. Thalassemia trait exerts a protective action only in subjects carrying PA allele for acid phosphatase. The data suggest that the gradient for malaria morbidity directly or indirectly, through interactions with thalassemia and G6PD polymorphisms, mediated by the habit of eating Vecia faba, may have had a significant role in determining the heterogeneous distribution of acid phosphatase polymorphism in Sardinia. Besides malaria, other environmental factors related with altitude seem to have been very important in shaping the present pattern of distribution of both acid phosphatase and G6PD polymorphisms in Sardinia.
R Palmarino, and
R Agostino, and
F Gloria, and
P Lucarelli, and
L Businco, and
G Antognoni, and
G Maggioni, and
P L Workman, and
E Bottini
January 1974,
Human heredity,
R Palmarino, and
R Agostino, and
F Gloria, and
P Lucarelli, and
L Businco, and
G Antognoni, and
G Maggioni, and
P L Workman, and
E Bottini
January 1973,
Human heredity,
R Palmarino, and
R Agostino, and
F Gloria, and
P Lucarelli, and
L Businco, and
G Antognoni, and
G Maggioni, and
P L Workman, and
E Bottini
January 1973,
Animal blood groups and biochemical genetics,
R Palmarino, and
R Agostino, and
F Gloria, and
P Lucarelli, and
L Businco, and
G Antognoni, and
G Maggioni, and
P L Workman, and
E Bottini
September 1963,
Nature,
R Palmarino, and
R Agostino, and
F Gloria, and
P Lucarelli, and
L Businco, and
G Antognoni, and
G Maggioni, and
P L Workman, and
E Bottini
January 1985,
Vox sanguinis,
R Palmarino, and
R Agostino, and
F Gloria, and
P Lucarelli, and
L Businco, and
G Antognoni, and
G Maggioni, and
P L Workman, and
E Bottini
January 1967,
Acta genetica et statistica medica,
R Palmarino, and
R Agostino, and
F Gloria, and
P Lucarelli, and
L Businco, and
G Antognoni, and
G Maggioni, and
P L Workman, and
E Bottini
April 1973,
Human heredity,
R Palmarino, and
R Agostino, and
F Gloria, and
P Lucarelli, and
L Businco, and
G Antognoni, and
G Maggioni, and
P L Workman, and
E Bottini
January 1970,
Humangenetik,
R Palmarino, and
R Agostino, and
F Gloria, and
P Lucarelli, and
L Businco, and
G Antognoni, and
G Maggioni, and
P L Workman, and
E Bottini
January 1975,
Acta geneticae medicae et gemellologiae,
R Palmarino, and
R Agostino, and
F Gloria, and
P Lucarelli, and
L Businco, and
G Antognoni, and
G Maggioni, and
P L Workman, and
E Bottini
June 1969,
Jinrui idengaku zasshi. The Japanese journal of human genetics,
