Effects of anterior hypothalamic lesions on the sexual behavior of prenatally-stressed male rats. 1977

J B Whitney, and L R Herrenkohl
Psychology Department, Temple University, Philadelphia, PA 19122, USA.

Sprague-Dawley females were exposed to the stress of heat, restraint and bright lights during the third trimester of gestation. Virtually all male offspring tested for masculine sexual behavior as adults ejaculated and copulated with lure females. Also prenatally-stressed males exhibited two to three times as many lordotic responses as did males from nonstressed mothers. Because animals were crossfostered, an in utero action of prenatal stress is supported. Anterior hypothalamic (AHA) lesions significantly reduced the number of lordotic responses observed in prenatally-stressed male rats compared to those observed in prenatally-stressed males bearing sham lesions of the AHA. The possibility is presented that prenatal stress may influence the developing male brain.

UI MeSH Term Description Entries
D007032 Hypothalamus, Anterior The front portion of the HYPOTHALAMUS separated into the preoptic region and the supraoptic region. The preoptic region is made up of the periventricular GRAY MATTER of the rostral portion of the THIRD VENTRICLE and contains the preoptic ventricular nucleus and the medial preoptic nucleus. The supraoptic region contains the PARAVENTRICULAR HYPOTHALAMIC NUCLEUS, the SUPRAOPTIC NUCLEUS, the ANTERIOR HYPOTHALAMIC NUCLEUS, and the SUPRACHIASMATIC NUCLEUS. Hypothalamus, Supraoptic,Anterior Hypothalamic Commissure,Anterior Hypothalamic Decussation of Ganser,Anteroventral Periventricular Nucleus,Anterior Hypothalamic Commissures,Anterior Hypothalamus,Commissure, Anterior Hypothalamic,Commissures, Anterior Hypothalamic,Hypothalamic Commissure, Anterior,Hypothalamic Commissures, Anterior,Nucleus, Anteroventral Periventricular,Periventricular Nucleus, Anteroventral,Supraoptic Hypothalamus
D008297 Male Males
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011297 Prenatal Exposure Delayed Effects The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH. Delayed Effects, Prenatal Exposure,Late Effects, Prenatal Exposure
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001143 Arousal Cortical vigilance or readiness of tone, presumed to be in response to sensory stimulation via the reticular activating system. Vigilance, Cortical,Arousals,Cortical Vigilance
D012726 Sexual Behavior, Animal Sexual activities of animals. Mating Behavior, Animal,Sex Behavior, Animal,Animal Mating Behavior,Animal Mating Behaviors,Animal Sex Behavior,Animal Sex Behaviors,Animal Sexual Behavior,Animal Sexual Behaviors,Mating Behaviors, Animal,Sex Behaviors, Animal,Sexual Behaviors, Animal
D012733 Sex Differentiation The process in developing sex- or gender-specific tissue, organ, or function after SEX DETERMINATION PROCESSES have set the sex of the GONADS. Major areas of sex differentiation occur in the reproductive tract (GENITALIA) and the brain. Differentiation, Sex,Sexual Differentiation,Differentiation, Sexual
D012741 Sexual Maturation Achievement of full sexual capacity in animals and in humans. Sex Maturation,Maturation, Sex,Maturation, Sexual

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