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A plasmid-mediated beta-lactamase with carbapenem-hydrolyzing activity from Serratia marcescens. 1999

N. Matsumura, and Akira Yotsuji, and Shinzaburo Minami, and Susumu Mitsuhashi
Toyama Chemical Co., Ltd., 2-5, Nishishinjuku 3-chome, Shinjuku-ku, Tokyo 160-0023, Japan; Episome Institute, 2220 Kogure, Fujimi-mura, Gunma, Japan.

Serratia marcescens W-313/pSW313 was isolated from a clinical specimen that showed resistance to various beta-lactams. beta-Lactamase from this strain hydrolyzed oxyiminocephalosporins and carbapenems, but did not hydrolyze 2-carboxypenam and aztreonam. The kinetic parameters of this enzyme were similar to those of the carbapenem-hydrolyzing beta-lactamases mediated by R-plasmid from Pseudomonas aeruginosa and S. marcescens, whose properties were previously reported.

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