Biomaterial Database

The P2Y1 receptor antagonist adenosine-2',5'-diphosphate non-selectively antagonizes the platelet P2X1 ion channel. 2001

E Toth-Zsamboki, and C Oury, and J Tytgat, and J Vermylen, and M F Hoylaerts

UI	MeSH Term	Description	Entries
D007473	Ion Channels	Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.	Membrane Channels,Ion Channel,Ionic Channel,Ionic Channels,Membrane Channel,Channel, Ion,Channel, Ionic,Channel, Membrane,Channels, Ion,Channels, Ionic,Channels, Membrane
D001792	Blood Platelets	Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.	Platelets,Thrombocytes,Blood Platelet,Platelet,Platelet, Blood,Platelets, Blood,Thrombocyte
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000244	Adenosine Diphosphate	Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.	ADP,Adenosine Pyrophosphate,Magnesium ADP,MgADP,Adenosine 5'-Pyrophosphate,5'-Pyrophosphate, Adenosine,ADP, Magnesium,Adenosine 5' Pyrophosphate,Diphosphate, Adenosine,Pyrophosphate, Adenosine
D013379	Substrate Specificity	A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.	Specificities, Substrate,Specificity, Substrate,Substrate Specificities
D058469	Receptors, Purinergic P2X	A subclass of purinergic P2 receptors that signal by means of a ligand-gated ion channel. They are comprised of three P2X subunits which can be identical (homotrimeric form) or dissimilar (heterotrimeric form).	P2X Purinoceptor,P2X Purinoceptors,P2X Receptors, Purinergic,Purinergic P2X Receptors,Purinoceptor, P2X,Purinoceptors, P2X
D058472	Receptors, Purinergic P2Y1	A subclass of purinergic P2Y receptors that have a preference for ATP and ADP. The activated P2Y1 receptor signals through the G-PROTEIN-coupled activation of PHOSPHOLIPASE C and mobilization of intracellular CALCIUM.	P2Y1 Purinoceptor,P2Y1 Purinoceptors,P2Y1 Receptor,P2Y1 Receptors,Purinergic Receptor P2Y, G-Protein Coupled, 1,Purinoceptor P2Y1,P2Y1 Receptors, Purinergic,Purinergic P2Y1 Receptors,Purinoceptor, P2Y1,Purinoceptors, P2Y1,Receptor, P2Y1,Receptors, P2Y1
D058919	Purinergic P2 Receptor Antagonists	Compounds that bind to and block the stimulation of PURINERGIC P2 RECEPTORS.	P2 Purinoceptor Antagonists,P2 Purinoceptor Blockers,Purinergic P2 Receptor Blockers,Antagonists, P2 Purinoceptor,Blockers, P2 Purinoceptor,Purinoceptor Antagonists, P2,Purinoceptor Blockers, P2