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Adult male rhesus were treated with PGE2, PGF2 alpha or the 13,14-dihydro-15-keto metabolite of PGE2 in a randomized crossover design. Serum concentrations of FSH, LH and testosterone were determined and compared to the respective values in the same uninjected animals. No significant changes were noted in controls or following the metabolite injection. FSH increased gradually for 4 hours after metabolite treatment. In contrast, injection of PGF2 alpha was followed by an abrupt (within 15 minutes) increase in LH and testosterone. FSH increased gradually in 2 of 3 treated animals. Injection of PGE2 was followed by a similar abrupt increase in LH concentration. This was not always associated with a significant increase in testosterone or FSH. These results demonstrate that injections of PGE2 or PGF2 alpha can change serum gonadotropin and testosterone concentrations in male rhesus monkeys, and that the effects of these two prostaglandins are qualitatively different.
F A Kimball, and
K T Kirton, and
A D Forbes, and
R D Frielink, and
S E Porteus, and
J W Wilks, and
N R Mohberg, and
L F Turner
November 1978,
Radiation research,
F A Kimball, and
K T Kirton, and
A D Forbes, and
R D Frielink, and
S E Porteus, and
J W Wilks, and
N R Mohberg, and
L F Turner
January 1993,
Acta Europaea fertilitatis,
F A Kimball, and
K T Kirton, and
A D Forbes, and
R D Frielink, and
S E Porteus, and
J W Wilks, and
N R Mohberg, and
L F Turner
January 1979,
Archives of sexual behavior,
F A Kimball, and
K T Kirton, and
A D Forbes, and
R D Frielink, and
S E Porteus, and
J W Wilks, and
N R Mohberg, and
L F Turner
February 1973,
Physiology & behavior,
F A Kimball, and
K T Kirton, and
A D Forbes, and
R D Frielink, and
S E Porteus, and
J W Wilks, and
N R Mohberg, and
L F Turner
January 1973,
Journal of reproduction and fertility,
F A Kimball, and
K T Kirton, and
A D Forbes, and
R D Frielink, and
S E Porteus, and
J W Wilks, and
N R Mohberg, and
L F Turner
August 1980,
Clinical endocrinology,
F A Kimball, and
K T Kirton, and
A D Forbes, and
R D Frielink, and
S E Porteus, and
J W Wilks, and
N R Mohberg, and
L F Turner
November 1974,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
F A Kimball, and
K T Kirton, and
A D Forbes, and
R D Frielink, and
S E Porteus, and
J W Wilks, and
N R Mohberg, and
L F Turner
May 1982,
International journal of sports medicine,
F A Kimball, and
K T Kirton, and
A D Forbes, and
R D Frielink, and
S E Porteus, and
J W Wilks, and
N R Mohberg, and
L F Turner
May 1978,
Archives of andrology,
F A Kimball, and
K T Kirton, and
A D Forbes, and
R D Frielink, and
S E Porteus, and
J W Wilks, and
N R Mohberg, and
L F Turner
January 1975,
Journal of reproduction and fertility,
