Biomaterial Database

Sodium-coupled bicarbonate transporters. 2001

W F Boron

Department of Cell and Molecular Physiology, Yale University School of Medicine. New Haven, CT 06520-8026, USA. walter.boron@yale.edu

Together, the Na(+)-coupled HCO(3)(-) transporters and the AE family of anion exchangers (i.e., Cl-HCO3 exchangers) comprise the bicarbonate transporter (BT) superfamily. Virtually all BTs are important for the regulation of intracellular pH (pH(i)) in cells throughout the body. Specific BTs also play roles in cell-volume regulation, as well as for the transport of salt and/or acid-base equivalents across many epithelia. Electrogenic Na/HCO3 cotransporters (NBCe's) play key roles in HCO(3)(-) reabsorption by the renal proximal tubule, and HCO(3)(-) secretion by the pancreatic duct. Electroneutral NBC's (NBCn's) regulate pH(i) in vascular smooth muscle and are present in/near axons in the brain. Finally, the Na(+)-driven Cl-HCO3 exchanger (NDCBE's) appear to be the major pH(i) regulators in CNS neurons. A characteristic of most, but not all, BT's is that they are inhibited rather effectively by 4,4'-diisothiocyanostilbene-4,4'-disulfonate (DIDS).

UI	MeSH Term	Description	Entries
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012964	Sodium	A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.	Sodium Ion Level,Sodium-23,Ion Level, Sodium,Level, Sodium Ion,Sodium 23
D027982	Sodium-Bicarbonate Symporters	Proteins that cotransport sodium ions and bicarbonate ions across cellular membranes.	SLC4A5 Protein,Electrogenic Sodium Bicarbonate Cotransporter 1,Electrogenic Sodium Bicarbonate Cotransporter 4,Electroneutral Na(+)-Driven Cl-HCO3 Exchanger,Electroneutral Sodium Bicarbonate Exchanger 1,NBC1 Protein,NBC3 Protein,NBC4 Protein,NBCE1 Protein,NBCe2 Protein,NBCn2 Protein,NCBE Protein,Na-HCO3 Symport,SLC4A10 Protein,SLC4A4 Protein,SLC4A7 Protein,SLC4A8 Protein,Sodium Bicarbonate Cotransporter 2,Sodium Bicarbonate Cotransporter 3,Sodium Bicarbonate Symport,Sodium-Bicarbonate Cotransporter,Sodium-Coupled Bicarbonate Transporters,Sodium-driven chloride bicarbonate exchanger,Solute Carrier Family 4 Member 10,Solute Carrier Family 4 Member 4,Solute Carrier Family 4 Member 5,Solute Carrier Family 4 Member 7,Solute Carrier Family 4 Member 8,Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 10,Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4,Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 5,Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 7,Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 8,k-NBC3 Protein,Bicarbonate Symport, Sodium,Bicarbonate Transporters, Sodium-Coupled,Cotransporter, Sodium-Bicarbonate,Na HCO3 Symport,Protein, NBC1,Protein, NBC3,Protein, NBC4,Protein, NBCE1,Protein, NBCe2,Protein, NBCn2,Protein, SLC4A10,Protein, SLC4A4,Protein, SLC4A5,Protein, SLC4A7,Protein, SLC4A8,Protein, k-NBC3,Sodium Bicarbonate Cotransporter,Sodium Bicarbonate Symporters,Sodium Coupled Bicarbonate Transporters,Sodium driven chloride bicarbonate exchanger,Symport, Na-HCO3,Symport, Sodium Bicarbonate,Symporters, Sodium-Bicarbonate,Transporters, Sodium-Coupled Bicarbonate,k NBC3 Protein