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Antigens of Fasciola hepatica adult worms were chromatographed using concanavalin A-Sepharose 4B. Two unbound peaks appeared in the inclusion volume (DT-1 and DT-2), and one peak was eluted with alpha-methylglucoside (E1-1). At least seven peaks were obtained by isoelectric focusing of E1-1. The largest of these peaks, with an average pI of 4.0, contained the antigens reactive with antibodies to Schistosoma mansoni. Mice immunized with DT-2 or E1-1 and challenged with S. mansoni cercariae developed 39 to 82% fewer worms than controls. DT-1 had no protective effect. Combining DT-1 and DT-2 abolished this protection. These experiments demonstrate that F. hepatica glycoprotein antigens induce in mice significant protection to infection with S. mansoni and offer an interesting approach to the study of vaccines in experimental schistosomiasis.
G V Hillyer, and
L Sagramoso de Ateca
October 1979,
Experimental parasitology,
G V Hillyer, and
L Sagramoso de Ateca
May 1982,
The Journal of infectious diseases,
G V Hillyer, and
L Sagramoso de Ateca
June 1982,
Immunology,
G V Hillyer, and
L Sagramoso de Ateca
April 1987,
Parasitology,
G V Hillyer, and
L Sagramoso de Ateca
November 1978,
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G V Hillyer, and
L Sagramoso de Ateca
January 1986,
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G V Hillyer, and
L Sagramoso de Ateca
March 2003,
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G V Hillyer, and
L Sagramoso de Ateca
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Veterinary parasitology,
G V Hillyer, and
L Sagramoso de Ateca
October 1988,
The Journal of parasitology,
G V Hillyer, and
L Sagramoso de Ateca
November 1978,
The American journal of tropical medicine and hygiene,
