[Tetanus immunity during senescence (author's transl)]. 1975

H Finger, and E Habermann, and K Bracharz, and H Hof

The circulating concentrations of antibodies directed against tetanus toxoid were determined by means of the mouse protection test in the serum samples of 2554 patients with an age between 60 and 98 years. Additionally, a part of the sera was tested by a radioimmunologic procedure. Immunity (neutralizing antitoxin titer greater than or equal to 0.01 International Units/ml serum) was only demonstrable in a small percent of the samples (15.3%). Compared to women, a larger percentage of men were found to be protected. Active immunization of aged persons (60-93 years old) resulted in the finding that usually also during senescence powerful immunity may develop following suitable vaccination.

UI MeSH Term Description Entries
D007110 Immunity, Active Resistance to a disease agent resulting from the production of specific antibodies by the host, either after exposure to the disease or after vaccination. Active Immune Response,Active Immune Responses,Active Immunities,Active Immunity,Immune Response, Active,Immune Responses, Active,Immunities, Active,Response, Active Immune,Responses, Active Immune
D007114 Immunization Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow). Immunologic Stimulation,Immunostimulation,Sensitization, Immunologic,Variolation,Immunologic Sensitization,Immunological Stimulation,Sensitization, Immunological,Stimulation, Immunologic,Immunizations,Immunological Sensitization,Immunological Sensitizations,Immunological Stimulations,Sensitizations, Immunological,Stimulation, Immunological,Stimulations, Immunological,Variolations
D007279 Injections, Subcutaneous Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin. Subcutaneous Injections,Injection, Subcutaneous,Subcutaneous Injection
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D013742 Tetanus A disease caused by tetanospasmin, a powerful protein toxin produced by CLOSTRIDIUM TETANI. Tetanus usually occurs after an acute injury, such as a puncture wound or laceration. Generalized tetanus, the most common form, is characterized by tetanic muscular contractions and hyperreflexia. Localized tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalized form. Clostridium tetani Infection,Clostridium tetani Infections,Infection, Clostridium tetani,Infections, Clostridium tetani
D013743 Tetanus Antitoxin An antitoxin used for the treatment of TETANUS. Antitoxin, Tetanus

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