-transparent.png){kind=logo}
Cell-mediated immunity was evaluated in 23 patients with systemic lupus erythematosus (SLE) prior to therapy and in 23 control subjects. The patients with SLE who had moderate to severe disease activity had significantly fewer positive delayed skin tests to streptokinase-streptodornase (SK-SD) and Candida than the control subjects, and a higher frequency of anergy than either the control subjects or the patients with mild SLE. Significant impairment of lymphocyte transformation to all common antigens tested was found in patients with SLE as compared to both normal subjects and control subjects with disease. Phytohemagglutinin response was reduced in patients with SLE as compared to normal subjects but not to the control subjects with disease. Lymphocyte transformation responses to SK-SD and Candida were also significantly lower in patients with moderate to severe SLE as compared to patients with mildly active SLE. Primary immune response to keyhole limpet hemocyanin (KLH) was impaired in patients with SLE as measured by lymphocyte transformation and total KLH antibody, but not 2-mercaptoethanol resistant antibody. The data indicate defective T-cell function in SLE, and suggest that the impairment relates in part to disease activity.
J G Paty, and
C W Sienknecht, and
A S Townes, and
A S Hanissian, and
J B Miller, and
A T Masi
October 1977,
Clinical and experimental immunology,
J G Paty, and
C W Sienknecht, and
A S Townes, and
A S Hanissian, and
J B Miller, and
A T Masi
June 1975,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
J G Paty, and
C W Sienknecht, and
A S Townes, and
A S Hanissian, and
J B Miller, and
A T Masi
December 2018,
Asian Pacific journal of cancer prevention : APJCP,
J G Paty, and
C W Sienknecht, and
A S Townes, and
A S Hanissian, and
J B Miller, and
A T Masi
January 1993,
Nihon rinsho. Japanese journal of clinical medicine,
J G Paty, and
C W Sienknecht, and
A S Townes, and
A S Hanissian, and
J B Miller, and
A T Masi
December 1975,
Die Medizinische Welt,
J G Paty, and
C W Sienknecht, and
A S Townes, and
A S Hanissian, and
J B Miller, and
A T Masi
November 2006,
Ginekologia polska,
J G Paty, and
C W Sienknecht, and
A S Townes, and
A S Hanissian, and
J B Miller, and
A T Masi
February 1977,
Archives of dermatology,
J G Paty, and
C W Sienknecht, and
A S Townes, and
A S Hanissian, and
J B Miller, and
A T Masi
June 1993,
Minerva medica,
J G Paty, and
C W Sienknecht, and
A S Townes, and
A S Hanissian, and
J B Miller, and
A T Masi
January 1991,
Clinical and experimental rheumatology,
J G Paty, and
C W Sienknecht, and
A S Townes, and
A S Hanissian, and
J B Miller, and
A T Masi
October 2018,
Annals of the rheumatic diseases,
