-transparent.png){kind=logo}
Philadelphia-positive T-cell acute lymphoblastic leukemia with polymyositis, migratory polyarthritis and hypercalcemia following a chronic myeloid leukemia. 2002
M Lima, and
J Coutinho, and
L Bernardo, and
M dos Anjos Teixeira, and
C Casais, and
A Canelhas, and
L Queirós, and
A Orfão, and
B Justiça
Department of Clinical Hematology, Hospital Geral de Santo António, Rua D Manuel II, s/n, 4099-001 Porto, Portugal. mmc.lima@clix.pt
Transformation of chronic myeloid leukemia (CML) often results in acute myeloblastic or, less frequently, in precursor B-cell acute lymphoblastic leukemia (ALL). T-cell blast crisis is rare. Hypercalcemia has also been described as a rare complication of CML, but this usually occurs as a terminal event. Here we report a case of a 35-year-old woman who developed a CD4(+)/CD8(+) T-cell ALL 2 years after the diagnosis of a typical Ph(+) CML. Polymyositis and polyarthritis preceded by 4 months, and symptomatic hypercalcemia occurred just before blastic transformation, probably representing paraneoplastic manifestations of the disease.
Related Publications
M Lima, and
J Coutinho, and
L Bernardo, and
M dos Anjos Teixeira, and
C Casais, and
A Canelhas, and
L Queirós, and
A Orfão, and
B Justiça
April 1989,
Leukemia,
M Lima, and
J Coutinho, and
L Bernardo, and
M dos Anjos Teixeira, and
C Casais, and
A Canelhas, and
L Queirós, and
A Orfão, and
B Justiça
June 2001,
Leukemia & lymphoma,
M Lima, and
J Coutinho, and
L Bernardo, and
M dos Anjos Teixeira, and
C Casais, and
A Canelhas, and
L Queirós, and
A Orfão, and
B Justiça
April 1985,
Cancer genetics and cytogenetics,
M Lima, and
J Coutinho, and
L Bernardo, and
M dos Anjos Teixeira, and
C Casais, and
A Canelhas, and
L Queirós, and
A Orfão, and
B Justiça
January 2008,
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy,
M Lima, and
J Coutinho, and
L Bernardo, and
M dos Anjos Teixeira, and
C Casais, and
A Canelhas, and
L Queirós, and
A Orfão, and
B Justiça
July 1985,
Clinical pediatrics,
M Lima, and
J Coutinho, and
L Bernardo, and
M dos Anjos Teixeira, and
C Casais, and
A Canelhas, and
L Queirós, and
A Orfão, and
B Justiça
February 2024,
The Journal of international medical research,
M Lima, and
J Coutinho, and
L Bernardo, and
M dos Anjos Teixeira, and
C Casais, and
A Canelhas, and
L Queirós, and
A Orfão, and
B Justiça
February 2012,
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy,
M Lima, and
J Coutinho, and
L Bernardo, and
M dos Anjos Teixeira, and
C Casais, and
A Canelhas, and
L Queirós, and
A Orfão, and
B Justiça
October 1988,
Cancer genetics and cytogenetics,
M Lima, and
J Coutinho, and
L Bernardo, and
M dos Anjos Teixeira, and
C Casais, and
A Canelhas, and
L Queirós, and
A Orfão, and
B Justiça
March 2015,
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion,
M Lima, and
J Coutinho, and
L Bernardo, and
M dos Anjos Teixeira, and
C Casais, and
A Canelhas, and
L Queirós, and
A Orfão, and
B Justiça
August 2016,
Journal of pediatric hematology/oncology,
