BIOMAT Database Logo BIOMAT Database Logo

Metabolism and metabolic effects of 8-aza-6-thioinosine and its rearrangement product, N-beta-D-ribofuranosyl-[1,2,3]thiadiazolo[5,4-d]-pyrimidin-7-amine. 1979

L L Bennett, and L M Rose, and P W Allan, and D Smithers, and D J Adamson, and R D Elliott, and J A Montgomery

UI MeSH Term Description Entries
D007288 Inosine A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
D007700 Kinetics The rate dynamics in chemical or physical systems.
D011683 Purine-Nucleoside Phosphorylase An enzyme that catalyzes the reaction between a purine nucleoside and orthophosphate to form a free purine plus ribose-5-phosphate. EC 2.4.2.1. Inosine Phosphorylase,Nicotinamide Riboside Phosphorylase,Purine Nucleoside Phosphorylases,Nucleoside Phosphorylases, Purine,Phosphorylase, Inosine,Phosphorylase, Nicotinamide Riboside,Phosphorylase, Purine-Nucleoside,Phosphorylases, Purine Nucleoside,Purine Nucleoside Phosphorylase,Riboside Phosphorylase, Nicotinamide
D006867 Hydrolases Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3. Hydrolase
D000248 Adenosine Kinase An enzyme that catalyzes the formation of ADP plus AMP from adenosine plus ATP. It can serve as a salvage mechanism for returning adenosine to nucleic acids. EC 2.7.1.20. Kinase, Adenosine
D013868 Thioinosine Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503) 6-Mercaptopurine Riboside,NSC-4911,Ribosyl-6-mercaptopurine,6 Mercaptopurine Riboside,Riboside, 6-Mercaptopurine,Ribosyl 6 mercaptopurine
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

Related Publications

L L Bennett, and L M Rose, and P W Allan, and D Smithers, and D J Adamson, and R D Elliott, and J A Montgomery
Synthesis and biological activity of selected 2-substituted 6-(beta-D-ribofuranosyl)oxazolo(5,4-d)pyrimidin-7-ones.
December 1974, Journal of medicinal chemistry,
L L Bennett, and L M Rose, and P W Allan, and D Smithers, and D J Adamson, and R D Elliott, and J A Montgomery
Synthesis of V-triazolo(4,5-c)pyridine nucleosides and 4-(beta-D-ribofuranosyl)amino-1,2,3-thiadiazolo(5,4-b)pyridine via a rearrangement.
April 1976, The Journal of organic chemistry,
L L Bennett, and L M Rose, and P W Allan, and D Smithers, and D J Adamson, and R D Elliott, and J A Montgomery
Antihypertensive activity of 6-arylpyrido[2,3-d]pyrimidin-7-amine derivatives.
April 1981, Journal of medicinal chemistry,
L L Bennett, and L M Rose, and P W Allan, and D Smithers, and D J Adamson, and R D Elliott, and J A Montgomery
6-(2,6-Dimethyl-phen-yl)pyrido[2,3-d]pyrimidin-7-amine.
February 2009, Acta crystallographica. Section E, Structure reports online,
L L Bennett, and L M Rose, and P W Allan, and D Smithers, and D J Adamson, and R D Elliott, and J A Montgomery
Synthesis and cytotoxicity studies of 8-amino-6-methyl-2-beta-D-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthyle ne (7-aza-TCN) and the corresponding 2'-deoxy- and arabinonucleoside analogues.
December 1990, Journal of medicinal chemistry,
L L Bennett, and L M Rose, and P W Allan, and D Smithers, and D J Adamson, and R D Elliott, and J A Montgomery
Antihypertensive activity of 6-arylpyrido[2,3-d]pyrimidin-7-amine derivatives. 2. 7-Acyl amide analogues.
March 1983, Journal of medicinal chemistry,
L L Bennett, and L M Rose, and P W Allan, and D Smithers, and D J Adamson, and R D Elliott, and J A Montgomery
Synthesis and antiallergy activity of [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives. II. 6-Alkyl- and 6-cycloalkylalkyl derivatives.
September 1992, Chemical & pharmaceutical bulletin,
L L Bennett, and L M Rose, and P W Allan, and D Smithers, and D J Adamson, and R D Elliott, and J A Montgomery
Synthesis of 2-substituted 9-oxa-guanines {5-aminooxazolo[5,4-d]pyrimidin-7(6H)-ones} and 9-oxa-2-thio-xanthines {5-mercaptooxazolo[5,4-d]pyrimidin-7(6H)-ones}.
January 2008, Beilstein journal of organic chemistry,
L L Bennett, and L M Rose, and P W Allan, and D Smithers, and D J Adamson, and R D Elliott, and J A Montgomery
3-Benzyl-6-butyl-5-propyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-one.
November 2010, Acta crystallographica. Section E, Structure reports online,
L L Bennett, and L M Rose, and P W Allan, and D Smithers, and D J Adamson, and R D Elliott, and J A Montgomery
Antiallergic activity of 6-(2-cyclohexylethyl)-[1,3,4]thiadiazolo- [3,2-a]-1,2,3-triazolo-[4,5-d]pyrimidin-9(3H)-one (DS-4574) in rats.
January 1992, International archives of allergy and immunology,
Copied contents to your clipboard!