Periodontal changes in liver cirrhosis and post-transplantation patients. II: radiographic findings:. 2002

Orit Oettinger-Barak, and Eli E Machtei, and Shlomi Barak, and Yaacov Baruch, and Leon Ardekian, and Micha Peled
Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel. barakori@zahav.net.il

BACKGROUND Liver disease and transplantation affect bone turnover. The role of cylosporin A (CsA) in aggravating bone loss is controversial. The aim of the present study was to examine the effect of liver cirrhosis, transplantation, and immunosuppressive therapy with either CsA or tacrolimus on alveolar bone height. METHODS The experimental group consisted of 13 liver cirrhosis (LC) patients. A second experimental group included 24 post-liver transplantation patients (PT) receiving CsA or tacrolimus. Seventeen healthy subjects formed a control group. Panoramic x-rays were taken and digitized using a computer-based measurement software to assess alveolar bone height of all available teeth. RESULTS Bone loss in the PT group (4.57+/-0.56 mm) was significantly higher than the control (C) (2.73+/-0.38 mm); however, it was significantly lower (P = 0.0005) than the LC (6.47+/-0.75 mm). Likewise, alveolar bone loss showed a trend for negative correlation (R = 0.404, P = 0.06) with the duration of immunosuppressive therapy post-liver transplantation. CONCLUSIONS Liver cirrhosis patients demonstrated greater bone loss compared to healthy controls. Restoration of liver functions following transplantation seems to have the potential to reverse some of these radiographic changes. Further longitudinal studies will be necessary to substantiate these findings.

UI MeSH Term Description Entries
D007166 Immunosuppressive Agents Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D008103 Liver Cirrhosis Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. Cirrhosis, Liver,Fibrosis, Liver,Hepatic Cirrhosis,Liver Fibrosis,Cirrhosis, Hepatic
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011859 Radiography Examination of any part of the body for diagnostic purposes by means of X-RAYS or GAMMA RAYS, recording the image on a sensitized surface (such as photographic film). Radiology, Diagnostic X-Ray,Roentgenography,X-Ray, Diagnostic,Diagnostic X-Ray,Diagnostic X-Ray Radiology,X-Ray Radiology, Diagnostic,Diagnostic X Ray,Diagnostic X Ray Radiology,Diagnostic X-Rays,Radiology, Diagnostic X Ray,X Ray Radiology, Diagnostic,X Ray, Diagnostic,X-Rays, Diagnostic
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000704 Analysis of Variance A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable. ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D016022 Case-Control Studies Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time. Case-Base Studies,Case-Comparison Studies,Case-Referent Studies,Matched Case-Control Studies,Nested Case-Control Studies,Case Control Studies,Case-Compeer Studies,Case-Referrent Studies,Case Base Studies,Case Comparison Studies,Case Control Study,Case Referent Studies,Case Referrent Studies,Case-Comparison Study,Case-Control Studies, Matched,Case-Control Studies, Nested,Case-Control Study,Case-Control Study, Matched,Case-Control Study, Nested,Case-Referent Study,Case-Referrent Study,Matched Case Control Studies,Matched Case-Control Study,Nested Case Control Studies,Nested Case-Control Study,Studies, Case Control,Studies, Case-Base,Studies, Case-Comparison,Studies, Case-Compeer,Studies, Case-Control,Studies, Case-Referent,Studies, Case-Referrent,Studies, Matched Case-Control,Studies, Nested Case-Control,Study, Case Control,Study, Case-Comparison,Study, Case-Control,Study, Case-Referent,Study, Case-Referrent,Study, Matched Case-Control,Study, Nested Case-Control
D016031 Liver Transplantation The transference of a part of or an entire liver from one human or animal to another. Grafting, Liver,Hepatic Transplantation,Liver Transplant,Transplantation, Hepatic,Transplantation, Liver,Hepatic Transplantations,Liver Grafting,Liver Transplantations,Liver Transplants,Transplant, Liver

Related Publications

Orit Oettinger-Barak, and Eli E Machtei, and Shlomi Barak, and Yaacov Baruch, and Leon Ardekian, and Micha Peled
March 1993, Hepatology (Baltimore, Md.),
Orit Oettinger-Barak, and Eli E Machtei, and Shlomi Barak, and Yaacov Baruch, and Leon Ardekian, and Micha Peled
January 1981, Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi,
Orit Oettinger-Barak, and Eli E Machtei, and Shlomi Barak, and Yaacov Baruch, and Leon Ardekian, and Micha Peled
December 2018, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society,
Orit Oettinger-Barak, and Eli E Machtei, and Shlomi Barak, and Yaacov Baruch, and Leon Ardekian, and Micha Peled
November 2002, Human pathology,
Orit Oettinger-Barak, and Eli E Machtei, and Shlomi Barak, and Yaacov Baruch, and Leon Ardekian, and Micha Peled
December 1963, Medizinische Klinik,
Orit Oettinger-Barak, and Eli E Machtei, and Shlomi Barak, and Yaacov Baruch, and Leon Ardekian, and Micha Peled
May 1974, The Journal of the Wisconsin Dental Association,
Orit Oettinger-Barak, and Eli E Machtei, and Shlomi Barak, and Yaacov Baruch, and Leon Ardekian, and Micha Peled
January 2002, Abdominal imaging,
Orit Oettinger-Barak, and Eli E Machtei, and Shlomi Barak, and Yaacov Baruch, and Leon Ardekian, and Micha Peled
June 2014, Journal of gastroenterology and hepatology,
Orit Oettinger-Barak, and Eli E Machtei, and Shlomi Barak, and Yaacov Baruch, and Leon Ardekian, and Micha Peled
February 1993, Polskie Archiwum Medycyny Wewnetrznej,
Orit Oettinger-Barak, and Eli E Machtei, and Shlomi Barak, and Yaacov Baruch, and Leon Ardekian, and Micha Peled
April 2017, Clinical oral investigations,
Copied contents to your clipboard!