BIOMAT Database Logo BIOMAT Database Logo

Antiviral activity of Rwandan medicinal plants against human immunodeficiency virus type-1 (HIV-1). 2002

P Cos, and N Hermans, and Bruyne T De, and S Apers, and J B Sindambiwe, and M Witvrouw, and Clercq E De, and Berghe D Vanden, and L Pieters, and A J Vlietinck
Faculty of Pharmaceutical Sciences, University of Antwerp, Belgium.

Selected plants used in Rwandan traditional medicine for the treatment of infections and/or rheumatoid diseases were investigated for antiviral activity in vitro against human immunodeficiency virus type-1 (HIV-1). Of the 38 tested 80% ethanolic extracts, belonging to plants of 21 different families only the extracts from the leaves of Aspilia pluriseta (Asteraceae) and Rumex bequaertii (Polygonaceae) had interesting selectivity indices (SI = ratio of the 50% cytotoxic concentration to the 50% effective antiviral concentration) higher than 1. Further fractionation of the initially antivirally inactive ethanolic extract of Tithonia diversifolia, however, led to an aqueous fraction with a high anti-HIV-1 activity (SI > 461), indicating that the cytotoxicity of some plant components may mask the antiviral properties of the active plant substances in total plant extracts.

UI MeSH Term Description Entries
D008517 Phytotherapy Use of plants or herbs to treat diseases or to alleviate pain. Herb Therapy,Herbal Therapy
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012432 Rwanda A republic in eastern Africa, south of UGANDA, east of DEMOCRATIC REPUBLIC OF THE CONGO, west of TANZANIA. Its capital is Kigali. It was formerly part of the Belgian trust territory of Ruanda-Urund. Ruanda,Republic of Rwanda
D015497 HIV-1 The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte. Human immunodeficiency virus 1,HIV-I,Human Immunodeficiency Virus Type 1,Immunodeficiency Virus Type 1, Human
D015658 HIV Infections Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS). HTLV-III Infections,HTLV-III-LAV Infections,T-Lymphotropic Virus Type III Infections, Human,HIV Coinfection,Coinfection, HIV,Coinfections, HIV,HIV Coinfections,HIV Infection,HTLV III Infections,HTLV III LAV Infections,HTLV-III Infection,HTLV-III-LAV Infection,Infection, HIV,Infection, HTLV-III,Infection, HTLV-III-LAV,Infections, HIV,Infections, HTLV-III,Infections, HTLV-III-LAV,T Lymphotropic Virus Type III Infections, Human
D016488 Medicine, African Traditional A system of traditional medicine which is based on the beliefs and practices of the African peoples. It includes treatment by MEDICINAL PLANTS and other MATERIA MEDICA as well as by the ministrations of diviners, MEDICINE MEN, witch doctors, and sorcerers. African Medicine, Traditional,Traditional Medicine, African,African Medicine,African Traditional Medicine,Medicine, African,Medicine, Traditional African,Traditional African Medicine
D018514 Plant Structures The parts of plants, including SEEDS. Plant Components,Component, Plant,Components, Plant,Plant Component,Plant Structure,Structure, Plant,Structures, Plant
D019380 Anti-HIV Agents Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. AIDS Drug,AIDS Drugs,Anti-AIDS Agents,Anti-AIDS Drug,Anti-HIV Agent,Anti-HIV Drug,Anti-AIDS Drugs,Anti-HIV Drugs,Agent, Anti-HIV,Agents, Anti-AIDS,Agents, Anti-HIV,Anti AIDS Agents,Anti AIDS Drug,Anti AIDS Drugs,Anti HIV Agent,Anti HIV Agents,Anti HIV Drug,Anti HIV Drugs,Drug, AIDS,Drug, Anti-AIDS,Drug, Anti-HIV,Drugs, AIDS,Drugs, Anti-AIDS,Drugs, Anti-HIV

Related Publications

P Cos, and N Hermans, and Bruyne T De, and S Apers, and J B Sindambiwe, and M Witvrouw, and Clercq E De, and Berghe D Vanden, and L Pieters, and A J Vlietinck
Antiviral activity of Hawaiian medicinal plants against human immunodeficiency Virus Type-1 (HIV-1).
January 1996, Phytomedicine : international journal of phytotherapy and phytopharmacology,
P Cos, and N Hermans, and Bruyne T De, and S Apers, and J B Sindambiwe, and M Witvrouw, and Clercq E De, and Berghe D Vanden, and L Pieters, and A J Vlietinck
Antiviral activity against human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) of ethnobotanically selected Ethiopian medicinal plants.
February 2001, Phytotherapy research : PTR,
P Cos, and N Hermans, and Bruyne T De, and S Apers, and J B Sindambiwe, and M Witvrouw, and Clercq E De, and Berghe D Vanden, and L Pieters, and A J Vlietinck
Antiviral activity of fattiviracin FV-8 against human immunodeficiency virus type 1 (HIV-1).
March 2001, Bioscience, biotechnology, and biochemistry,
P Cos, and N Hermans, and Bruyne T De, and S Apers, and J B Sindambiwe, and M Witvrouw, and Clercq E De, and Berghe D Vanden, and L Pieters, and A J Vlietinck
Antiviral activity of some Tunisian medicinal plants against Herpes simplex virus type 1.
January 2008, Natural product research,
P Cos, and N Hermans, and Bruyne T De, and S Apers, and J B Sindambiwe, and M Witvrouw, and Clercq E De, and Berghe D Vanden, and L Pieters, and A J Vlietinck
Korean medicinal plants inhibiting to human immunodeficiency virus type 1 (HIV-1) fusion.
April 2003, Phytotherapy research : PTR,
P Cos, and N Hermans, and Bruyne T De, and S Apers, and J B Sindambiwe, and M Witvrouw, and Clercq E De, and Berghe D Vanden, and L Pieters, and A J Vlietinck
Antiviral activity of polyoxomolybdoeuropate PM-104 against human immunodeficiency virus type 1.
June 1991, Chemical & pharmaceutical bulletin,
P Cos, and N Hermans, and Bruyne T De, and S Apers, and J B Sindambiwe, and M Witvrouw, and Clercq E De, and Berghe D Vanden, and L Pieters, and A J Vlietinck
Antiviral activity of diterpenes isolated from the Brazilian marine alga Dictyota menstrualis against human immunodeficiency virus type 1 (HIV-1).
October 2004, Antiviral research,
P Cos, and N Hermans, and Bruyne T De, and S Apers, and J B Sindambiwe, and M Witvrouw, and Clercq E De, and Berghe D Vanden, and L Pieters, and A J Vlietinck
Antiviral action of oligodeoxyguanylic acids against human immunodeficiency virus type 1.
April 1995, AIDS research and human retroviruses,
P Cos, and N Hermans, and Bruyne T De, and S Apers, and J B Sindambiwe, and M Witvrouw, and Clercq E De, and Berghe D Vanden, and L Pieters, and A J Vlietinck
Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1.
August 2005, The Journal of general virology,
P Cos, and N Hermans, and Bruyne T De, and S Apers, and J B Sindambiwe, and M Witvrouw, and Clercq E De, and Berghe D Vanden, and L Pieters, and A J Vlietinck
The antiviral activity of the milk protein lactoferrin against the human immunodeficiency virus type 1.
June 2004, Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine,
Copied contents to your clipboard!