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The insulin secretory response to a sudden and sustained intravenous glycemic stimulus was measured in three groups of dogs whose antecedent carbohydrate intake ranged from zero to 300 or more grams daily. Insulin outflow rate from the pancreaticoduodenal vein was measured every minute for ten minutes, then at increasing intervals through sixty minutes. It was found that starvation erased the first phase of the biphasic insulin response shown by dogs on ordinary carbohydrate intake and that high-carbohydrate intake abolished the trough between the two phases. The data suggest that, during truly physiologic stimulation of insulin secretion, the latter represents the final stage of a continuum of hormonal synthesis, storage, and release, rather than emanating from one of two separate pools of fast-versus-slow insulin secretion.
Y Fujita, and
A R Chacra, and
A L Herron, and
H S Seltzer
December 1973,
The American journal of the medical sciences,
Y Fujita, and
A R Chacra, and
A L Herron, and
H S Seltzer
August 1971,
The Journal of clinical endocrinology and metabolism,
Y Fujita, and
A R Chacra, and
A L Herron, and
H S Seltzer
February 2008,
Endocrinology,
Y Fujita, and
A R Chacra, and
A L Herron, and
H S Seltzer
May 1972,
Metabolism: clinical and experimental,
Y Fujita, and
A R Chacra, and
A L Herron, and
H S Seltzer
August 1980,
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai,
Y Fujita, and
A R Chacra, and
A L Herron, and
H S Seltzer
April 2013,
Primary care diabetes,
Y Fujita, and
A R Chacra, and
A L Herron, and
H S Seltzer
July 1979,
Annals of surgery,
Y Fujita, and
A R Chacra, and
A L Herron, and
H S Seltzer
June 1972,
The Australian journal of experimental biology and medical science,
Y Fujita, and
A R Chacra, and
A L Herron, and
H S Seltzer
July 1973,
The Journal of laboratory and clinical medicine,
Y Fujita, and
A R Chacra, and
A L Herron, and
H S Seltzer
July 1988,
Diabetologia,
