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The effects of single and multiple seizures on cholecystokinin (CCK) mRNA levels in amygdala of audiogenic seizure-prone rats (P77PMC) were examined by in situ hybridization. The main results are as follows: (1) CCK mRNA positive neurons (No/0.01 mm(2)) in amygdala showed a transient increase in number from the 8+/-1 to 58+/-5 (P<0.01) in 30 min and then returned to the control value in 2 h (9+/-2, P>0.05), and (2) in the multiple consecutive seizure rats the increase in 30 min (22+/-3) was less than that in the single seizure rats (P<0.01), and the number returned to normal in 1 h (6+/-1, P>0.05). These data indicate that the transient increase in CCK mRNA level in amygdala following single or multiple consecutive seizures of P77PMC may be involved in anti-convulsant mechanisms in response to acute seizures.
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M Tang, and
S B wang
May 2000,
Acta pharmacologica Sinica,
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Seizure,
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Neuropharmacology,
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Brain research,
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March 1992,
Experimental neurology,
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January 1989,
Epilepsy research,
H Ni, and
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June 2015,
Neuroscience letters,
H Ni, and
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February 1999,
Experimental neurology,
H Ni, and
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January 1996,
Life sciences,
