Biomaterial Database

[K(ATP) channel opener facilitates carotid sinus baroreflex in anesthetized rats]. 2000

T Yin, and S Chen, and R R He

Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China.

The effects of cromakalim (Cro), a K(ATP) channel opener, on the carotid baroreflex were studied in 32 anesthetized rats with perfused isolated carotid sinus. The results obtained are as follows. (1) By perfusing the isolated carotid sinus with Cro (10 micromol/L), the functional curve of the baroreflex was shifted to the left and downward, with a peak slope (PS) increasing from 0.36+/-0.01 to 0.48+/-0.01 kPa/kPa (P<0.001), whereas the reflex decrease in mean arterial pressure (RD) was increased from 5.78+/-0.14 to 7.87+/-0.12 kPa (P<0.001). Meanwhile, the threshold pressure (TP), equilibrium pressure (EP) and saturation pressure (SP) were all significantly decreased from 8.34+/-0.35 to 6.41+/-0.09 kPa (P<0.01), 12.71+/-0.25 to 11.78+/-0.24 kPa (P<0.01) and 24.89+/-0.25 to 22.56+/-0.16 kPa (P<0.001), respectively. Among the functional parameters of carotid baroreflex, the changes in RD, PS and TP induced by Cro were dose-dependent. (2) By pretreatment with glibenclamide (10 micromol/L), a K(ATP) channel blocker, the above effects of Cro on the carotid baroreflex were abolished. (3) The Cro-induced change in the baroreflex was enhanced by preperfusing with adenosine (125 micromol/L). On the basis of the above results, it is concluded that Cro facilitates the carotid baroreflex, an effect attributable to the enhanced stretch of baroreceptors by dilation of sinus wall as a result of K(ATP) channel activation.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002346	Carotid Sinus	The dilated portion of the common carotid artery at its bifurcation into external and internal carotids. It contains baroreceptors which, when stimulated, cause slowing of the heart, vasodilatation, and a fall in blood pressure.	Sinus, Carotid
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014665	Vasodilator Agents	Drugs used to cause dilation of the blood vessels.	Vasoactive Antagonists,Vasodilator,Vasodilator Agent,Vasodilator Drug,Vasorelaxant,Vasodilator Drugs,Vasodilators,Vasorelaxants,Agent, Vasodilator,Agents, Vasodilator,Antagonists, Vasoactive,Drug, Vasodilator,Drugs, Vasodilator
D015221	Potassium Channels	Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.	Ion Channels, Potassium,Ion Channel, Potassium,Potassium Channel,Potassium Ion Channels,Channel, Potassium,Channel, Potassium Ion,Channels, Potassium,Channels, Potassium Ion,Potassium Ion Channel
D015640	Ion Channel Gating	The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.	Gating, Ion Channel,Gatings, Ion Channel,Ion Channel Gatings
D017207	Rats, Sprague-Dawley	A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.	Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D017704	Baroreflex	A response by the BARORECEPTORS to increased BLOOD PRESSURE. Increased pressure stretches BLOOD VESSELS which activates the baroreceptors in the vessel walls. The net response of the CENTRAL NERVOUS SYSTEM is a reduction of central sympathetic outflow. This reduces blood pressure both by decreasing peripheral VASCULAR RESISTANCE and by lowering CARDIAC OUTPUT. Because the baroreceptors are tonically active, the baroreflex can compensate rapidly for both increases and decreases in blood pressure.	Reflex, Baroreceptor,Baroreceptor Reflex,Baroreceptor Reflexes,Baroreflexes,Reflexes, Baroreceptor