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In two groups of juvenile onset diabetics similar in age, weight, diet and daily insulin dosage (eight without C-peptide, group I; eight with C-peptide, group II) the serum levels of free and antibody bound insulin, C-peptide, glucose, lactate, alanine and FFA were determined over 24 h. In addition the affinity and binding capacity of the insulin antibodies were determined in vitro. No correlation was found between free or bound insulin and glucose. This holds true for the individual profiles as well as for the averaged profiles of the two groups. Free insulin and lactate or alanine were positively correlated in the C-peptide secreting group. C-peptide secretion followed the flucturations of the glucose level during 24 h in each individual patient. As a group, C-peptide secretors were better controlled than non-secretors with respect to mean blood glucose, M-value and the lability index and showed higher free insulin levels despite a similar daily insulin dosage. The possible reasons for this fact are discussed. No correlation was found between the affinity characteristics of the insulin antibodies and the degree of metabolic control or the daily insulin dosage.
K D Gerbitz, and
W Kemmler, and
A Edelmann, and
J Summer, and
H Mehnert, and
O H Wieland
April 1977,
Endocrinologia japonica,
K D Gerbitz, and
W Kemmler, and
A Edelmann, and
J Summer, and
H Mehnert, and
O H Wieland
August 1985,
Diabetes,
K D Gerbitz, and
W Kemmler, and
A Edelmann, and
J Summer, and
H Mehnert, and
O H Wieland
August 1990,
Acta ophthalmologica,
K D Gerbitz, and
W Kemmler, and
A Edelmann, and
J Summer, and
H Mehnert, and
O H Wieland
January 1984,
Annals of clinical research,
K D Gerbitz, and
W Kemmler, and
A Edelmann, and
J Summer, and
H Mehnert, and
O H Wieland
September 1976,
Diabete & metabolisme,
K D Gerbitz, and
W Kemmler, and
A Edelmann, and
J Summer, and
H Mehnert, and
O H Wieland
January 1977,
Diabetes,
K D Gerbitz, and
W Kemmler, and
A Edelmann, and
J Summer, and
H Mehnert, and
O H Wieland
October 1981,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
K D Gerbitz, and
W Kemmler, and
A Edelmann, and
J Summer, and
H Mehnert, and
O H Wieland
November 1982,
Zhonghua yi xue za zhi,
K D Gerbitz, and
W Kemmler, and
A Edelmann, and
J Summer, and
H Mehnert, and
O H Wieland
January 1983,
Acta diabetologica latina,
K D Gerbitz, and
W Kemmler, and
A Edelmann, and
J Summer, and
H Mehnert, and
O H Wieland
February 1978,
Acta endocrinologica,
