Biomaterial Database

[Salvage therapy in HIV disease]. 2002

Atsushi Ajisawa

Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital.

Highly active antiretroviral treatment(HAART) is very effective for Japanese Human immunodeficiency virus(HIV) patients in the morbidity and mortality. But the need for salvage therapy is related to the imperfection of current antiretroviral therapy. HIV-RNA load will be detectable in approximately 40% of non-naive HIV patients who are taking triple therapy after 1 year of follow-up. Treatment failure may be related to poor adherence, resistant virus and poor pharmacological bioavailability. This article aims at describing the strategic thoughts in rapid development of pathophysiological as well as clinical and drug-related knowledge. Patient commitment, physician knowledge and an informed supportive environment are important to success in salvage therapy.

UI	MeSH Term	Description	Entries
D007564	Japan	A country in eastern Asia, island chain between the North Pacific Ocean and the Sea of Japan, east of the Korean Peninsula. The capital is Tokyo.	Bonin Islands
D010349	Patient Compliance	Voluntary cooperation of the patient in following a prescribed regimen.	Client Adherence,Client Compliance,Non-Adherent Patient,Patient Adherence,Patient Cooperation,Patient Noncompliance,Patient Non-Adherence,Patient Non-Compliance,Patient Nonadherence,Therapeutic Compliance,Treatment Compliance,Adherence, Client,Adherence, Patient,Client Compliances,Compliance, Client,Compliance, Patient,Compliance, Therapeutic,Compliance, Treatment,Cooperation, Patient,Non Adherent Patient,Non-Adherence, Patient,Non-Adherent Patients,Non-Compliance, Patient,Nonadherence, Patient,Noncompliance, Patient,Patient Non Adherence,Patient Non Compliance,Patient, Non-Adherent,Therapeutic Compliances,Treatment Compliances
D012017	Referral and Consultation	The practice of sending a patient to another program or practitioner for services or advice which the referring source is not prepared to provide.	Consultation,Gatekeepers, Health Service,Hospital Referral,Second Opinion,Consultation and Referral,Health Service Gatekeepers,Hospital Referrals,Referral,Referral, Hospital,Referrals, Hospital,Consultations,Gatekeeper, Health Service,Health Service Gatekeeper,Opinion, Second,Opinions, Second,Referrals,Second Opinions
D004359	Drug Therapy, Combination	Therapy with two or more separate preparations given for a combined effect.	Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015658	HIV Infections	Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).	HTLV-III Infections,HTLV-III-LAV Infections,T-Lymphotropic Virus Type III Infections, Human,HIV Coinfection,Coinfection, HIV,Coinfections, HIV,HIV Coinfections,HIV Infection,HTLV III Infections,HTLV III LAV Infections,HTLV-III Infection,HTLV-III-LAV Infection,Infection, HIV,Infection, HTLV-III,Infection, HTLV-III-LAV,Infections, HIV,Infections, HTLV-III,Infections, HTLV-III-LAV,T Lymphotropic Virus Type III Infections, Human
D016879	Salvage Therapy	A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.	Salvage Treatment,Therapy, Salvage,Salvage Therapies,Salvage Treatments,Therapies, Salvage,Treatment, Salvage,Treatments, Salvage
D017211	Treatment Failure	A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.	Failure, Treatment,Failures, Treatment,Treatment Failures
D017320	HIV Protease Inhibitors	Inhibitors of HIV PROTEASE, an enzyme required for production of proteins needed for viral assembly.	HIV Protease Inhibitor,Inhibitor, HIV Protease,Inhibitors, HIV Protease,Protease Inhibitor, HIV,Protease Inhibitors, HIV
D018894	Reverse Transcriptase Inhibitors	Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template.	Reverse Transcriptase Inhibitor,Inhibitors, Reverse Transcriptase,Inhibitor, Reverse Transcriptase,Transcriptase Inhibitor, Reverse

Related Publications

Atsushi Ajisawa

[Salvage therapy in HIV infection].

April 2004, MMW Fortschritte der Medizin,

Atsushi Ajisawa

Salvage treatment in HIV disease.

May 2001, International journal of STD & AIDS,

Atsushi Ajisawa

Salvage antiretroviral therapy in HIV infection.

February 2002, Expert opinion on pharmacotherapy,

Atsushi Ajisawa

[Salvage therapy for HIV infection].

April 2005, MMW Fortschritte der Medizin,

Atsushi Ajisawa

Clinical experience with stavudine as salvage therapy in patients with advanced HIV disease.

September 1996, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association,

Atsushi Ajisawa

Salvage therapy for metastatic disease.

August 1990, Seminars in oncology,

Atsushi Ajisawa

Use of rituximab as a salvage therapy for HIV-associated multicentric Castleman disease.

March 2006, Annals of hematology,

Atsushi Ajisawa

[Safety and effectiveness of salvage therapy in HIV patients].

January 2012, Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria,

Atsushi Ajisawa

Tipranavir: a protease inhibitor for HIV salvage therapy.

January 2006, The Annals of pharmacotherapy,