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FcR nonbinding anti-CD3 epsilon mAbs elicit partial TCR signaling that leads to T cell unresponsiveness and tolerance in vivo. In this study, the membrane-proximal events that promote T cell inactivation by FcR nonbinding anti-CD3 mAbs were examined. In the context of FcR nonbinding anti-CD3, TCR complexes did not aggregate and failed to translocate into glycolipid-enriched membrane microdomains. Furthermore, FcR nonbinding anti-CD3 mAbs induced tyrosine phosphorylation of the Fyn substrate Cbl, but not the ZAP-70 substrate linker for activation of T cells. Overexpression of Fyn, but not Lck, restored the mitogenicity of FcR nonbinding anti-CD3 in primary T cells. Taken together, these results suggest that Fyn mediates the partial signaling induced by TCR antagonists.
Qizhi Tang, and
Sumit K Subudhi, and
Kammi J Henriksen, and
Catherine G Long, and
Franklin Vives, and
Jeffrey A Bluestone
December 2011,
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Qizhi Tang, and
Sumit K Subudhi, and
Kammi J Henriksen, and
Catherine G Long, and
Franklin Vives, and
Jeffrey A Bluestone
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Kammi J Henriksen, and
Catherine G Long, and
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Jeffrey A Bluestone
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Jeffrey A Bluestone
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Kammi J Henriksen, and
Catherine G Long, and
Franklin Vives, and
Jeffrey A Bluestone
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Kammi J Henriksen, and
Catherine G Long, and
Franklin Vives, and
Jeffrey A Bluestone
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Kammi J Henriksen, and
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Jeffrey A Bluestone
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Sumit K Subudhi, and
Kammi J Henriksen, and
Catherine G Long, and
Franklin Vives, and
Jeffrey A Bluestone
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Qizhi Tang, and
Sumit K Subudhi, and
Kammi J Henriksen, and
Catherine G Long, and
Franklin Vives, and
Jeffrey A Bluestone
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Qizhi Tang, and
Sumit K Subudhi, and
Kammi J Henriksen, and
Catherine G Long, and
Franklin Vives, and
Jeffrey A Bluestone
May 2007,
Cell metabolism,
