Successful cyclophosphamide therapy in recurrent eosinophilic colitis associated with hypereosinophilic syndrome. 2002

Ju Hee Lee, and Jin Woo Lee, and Cheol Soon Jang, and Eun Sang Kwon, and Hyo Young Min, and Seok Jeong, and Kye Sook Kwon, and Don Haeng Lee, and Hyeon Geun Cho, and Pum Soo Kim, and Hyung Gil Kim, and Yong Woon Shin, and Young Soo Kim
Department of Internal Medicine, Inha University College of Medicine, Inchon, 400-103, Korea.

Eosinophilic colitis is a relatively rare complication of hypereosinophilic syndrome which is characterized by abdominal pain and bloody diarrhea and is usually treated with steroids and hydroxyurea. However, no standard regimen exists in cases of intractable disease despite several treatment attempts with Interferon-alpha, cyclosporin, etoposide, and vincristine, etc. We here report a case of a 43-year-old woman with recurrent eosinophilic colitis as a complication of hypereosinophilic syndrome who was successfully treated with cyclophosphamide.

UI MeSH Term Description Entries
D012008 Recurrence The return of a sign, symptom, or disease after a remission. Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D003092 Colitis Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER. Colitides
D003520 Cyclophosphamide Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. (+,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide Monohydrate,B-518,Cyclophosphamide Anhydrous,Cyclophosphamide Monohydrate,Cyclophosphamide, (R)-Isomer,Cyclophosphamide, (S)-Isomer,Cyclophosphane,Cytophosphan,Cytophosphane,Cytoxan,Endoxan,NSC-26271,Neosar,Procytox,Sendoxan,B 518,B518,NSC 26271,NSC26271
D004802 Eosinophilia Abnormal increase of EOSINOPHILS in the blood, tissues or organs. Eosinophilia, Tropical,Hypereosinophilia,Tropical Eosinophilia,Hypereosinophilias,Tropical Eosinophilias
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D017681 Hypereosinophilic Syndrome A heterogeneous group of disorders with the common feature of prolonged eosinophilia of unknown cause and associated organ system dysfunction, including the heart, central nervous system, kidneys, lungs, gastrointestinal tract, and skin. There is a massive increase in the number of EOSINOPHILS in the blood, mimicking leukemia, and extensive eosinophilic infiltration of the various organs. Endocarditis, Loeffler's,Idiopathic Hypereosinophilic Syndrome,Leukemia, Eosinophilic,Loeffler's Endocarditis,Endocarditis, Loeffler,Hypereosinophilic Syndrome, Idiopathic,Loeffler Endocarditis,Endocarditis, Loefflers,Eosinophilic Leukemia,Eosinophilic Leukemias,Hypereosinophilic Syndromes,Hypereosinophilic Syndromes, Idiopathic,Idiopathic Hypereosinophilic Syndromes,Leukemias, Eosinophilic,Loefflers Endocarditis,Syndrome, Hypereosinophilic,Syndrome, Idiopathic Hypereosinophilic,Syndromes, Hypereosinophilic,Syndromes, Idiopathic Hypereosinophilic

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