Biomaterial Database

Immunoglobulin-E and anti-IgE treatment in lung disease. 2001

R K Chitkara, and P S Sarinas, and R B Fick

Division of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, San Francisco, CA, USA.

A highly specific monoclonal antibody binding IgE (anti-IgE/omalizumab) has made it possible to determine the immunopathogenetic role that this reaginic antibody plays in human allergic disease. It is clear from recently completed studies that IgE is essential to the full generation of early and late asthmatic responses in human bronchoprovocation trials. Importantly, anti-IgE treatment of severe asthma disease significantly improves symptoms and reduces exacerbation episodes. Elevated serum levels of IgE are prominent in the clinical presentation of allergic bronchopulmonary mycoses and IgE-mediated Type I hypersensitivity reactions are of fundamental importance to the immunopathogenesis of allergic bronchopulmonary aspergillosis. Although the role of IgE in mediating immunity to helminth parasites is considerably less clear, it is safe to conclude that the overall balance of evidence does not support a primary role for IgE in host protection with regard to schistosomiasis and strongyloidiasis.

UI	MeSH Term	Description	Entries
D007073	Immunoglobulin E	An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).	IgE
D008174	Lung Diseases, Parasitic	Infections of the lungs with parasites, most commonly by parasitic worms (HELMINTHS).	Parasitic Lung Diseases,Parasitic Infections of Lung,Pulmonary Parasitic Infections,Lung Disease, Parasitic,Lung Parasitic Infection,Lung Parasitic Infections,Parasitic Infection, Pulmonary,Parasitic Infections, Pulmonary,Parasitic Lung Disease,Pulmonary Parasitic Infection
D004306	Dose-Response Relationship, Immunologic	A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.	Immunologic Dose-Response Relationship,Relationship, Immunologic Dose-Response,Dose Response Relationship, Immunologic,Dose-Response Relationships, Immunologic,Immunologic Dose Response Relationship,Immunologic Dose-Response Relationships,Relationship, Immunologic Dose Response,Relationships, Immunologic Dose-Response
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000888	Antibodies, Anti-Idiotypic	Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.	Anti-Antibodies,Anti-Idiotype Antibodies,Antibodies, Internal Image,Antigamma Globulin Antibodies,Antiglobulins,Anti Antibodies,Anti-gamma Globulin Antibodies,Anti Idiotype Antibodies,Anti gamma Globulin Antibodies,Anti-Idiotypic Antibodies,Antibodies, Anti,Antibodies, Anti Idiotypic,Antibodies, Anti-Idiotype,Antibodies, Anti-gamma Globulin,Antibodies, Antigamma Globulin,Globulin Antibodies, Anti-gamma,Globulin Antibodies, Antigamma,Image Antibodies, Internal,Internal Image Antibodies
D000911	Antibodies, Monoclonal	Antibodies produced by a single clone of cells.	Monoclonal Antibodies,Monoclonal Antibody,Antibody, Monoclonal
D001229	Aspergillosis, Allergic Bronchopulmonary	Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.	Allergic Bronchopulmonary Aspergillosis,Allergic Bronchopulmonary Aspergilloses,Aspergilloses, Allergic Bronchopulmonary,Aspergillosis, Bronchopulmonary Allergic,Bronchopulmonary Aspergilloses, Allergic,Bronchopulmonary Aspergillosis, Allergic,Allergic Aspergilloses, Bronchopulmonary,Allergic Aspergillosis, Bronchopulmonary,Aspergilloses, Bronchopulmonary Allergic,Bronchopulmonary Allergic Aspergilloses,Bronchopulmonary Allergic Aspergillosis
D001249	Asthma	A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	Asthma, Bronchial,Bronchial Asthma,Asthmas