Hypertension and coronary heart disease. 2002

E Escobar
University of Chile, Santiago, Chile.

The association of hypertension and coronary heart disease is a frequent one. There are several pathophysiologic mechanisms which link both diseases. Hypertension induces endothelial dysfunction, exacerbates the atherosclerotic process and it contributes to make the atherosclerotic plaque more unstable. Left ventricular hypertrophy, which is the usual complication of hypertension, promotes a decrease of 'coronary reserve' and increases myocardial oxygen demand, both mechanisms contributing to myocardial ischaemia. From a clinical point of view hypertensive patients should have a complete evaluation of risk factors for atherosclerosis, damage of arterial territories other than the coronary one, and of the extension and severity of coronary artery involvement. It is important to emphasise that complications and mortality of patients suffering a myocardial infarction are greater in hypertensive patients. Treatment should be aimed to achieve optimal values of blood pressure, and all the strategies to treat coronary heart disease should be considered on an individual basis.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D003327 Coronary Disease An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels. Coronary Heart Disease,Coronary Diseases,Coronary Heart Diseases,Disease, Coronary,Disease, Coronary Heart,Diseases, Coronary,Diseases, Coronary Heart,Heart Disease, Coronary,Heart Diseases, Coronary
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

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