BIOMAT Database Logo BIOMAT Database Logo

Synthesis and antifungal activity of new N-(1-phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides. 2002

Demetrio Raffa, and Giuseppe Daidone, and Fabiana Plescia, and Domenico Schillaci, and Benedetta Maggio, and Livio Torta
Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, Italy. demraffa@unipa.it

N-(1-Phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides 6, with a Benodanil-like structure, were synthesized by refluxing in acetic acid the corresponding benzotriazinones 5 with potassium iodide for 1 h in order to study the role on the antifungal activity of the N-substitution with an aromatic heterocyclic system on benzamide moiety. Among the tested iododerivatives, compounds 6d,f,g,h possess interesting activities toward some phytopathogenic fungal strains.

UI MeSH Term Description Entries
D007191 Indazoles A group of heterocyclic aromatic organic compounds consisting of the fusion of BENZENE and PYRAZOLES. Indazole
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D009682 Magnetic Resonance Spectroscopy Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING). In Vivo NMR Spectroscopy,MR Spectroscopy,Magnetic Resonance,NMR Spectroscopy,NMR Spectroscopy, In Vivo,Nuclear Magnetic Resonance,Spectroscopy, Magnetic Resonance,Spectroscopy, NMR,Spectroscopy, Nuclear Magnetic Resonance,Magnetic Resonance Spectroscopies,Magnetic Resonance, Nuclear,NMR Spectroscopies,Resonance Spectroscopy, Magnetic,Resonance, Magnetic,Resonance, Nuclear Magnetic,Spectroscopies, NMR,Spectroscopy, MR
D011720 Pyrazoles Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.
D005658 Fungi A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies. Fungi, Filamentous,Molds,Filamentous Fungi,Filamentous Fungus,Fungus,Fungus, Filamentous,Mold
D000935 Antifungal Agents Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. Anti-Fungal Agents,Antifungal Agent,Fungicides, Therapeutic,Antibiotics, Antifungal,Therapeutic Fungicides,Agent, Antifungal,Anti Fungal Agents,Antifungal Antibiotics
D001549 Benzamides BENZOIC ACID amides.
D013055 Spectrophotometry, Infrared Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) IR Spectra,Infrared Spectrophotometry,IR Spectras,Spectra, IR
D015169 Colony Count, Microbial Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing. Agar Dilution Count,Colony-Forming Units Assay, Microbial,Fungal Count,Pour Plate Count,Spore Count,Spread Plate Count,Streak Plate Count,Colony Forming Units Assay, Microbial,Colony Forming Units Assays, Microbial,Agar Dilution Counts,Colony Counts, Microbial,Count, Agar Dilution,Count, Fungal,Count, Microbial Colony,Count, Pour Plate,Count, Spore,Count, Spread Plate,Count, Streak Plate,Counts, Agar Dilution,Counts, Fungal,Counts, Microbial Colony,Counts, Pour Plate,Counts, Spore,Counts, Spread Plate,Counts, Streak Plate,Dilution Count, Agar,Dilution Counts, Agar,Fungal Counts,Microbial Colony Count,Microbial Colony Counts,Pour Plate Counts,Spore Counts,Spread Plate Counts,Streak Plate Counts

Related Publications

Demetrio Raffa, and Giuseppe Daidone, and Fabiana Plescia, and Domenico Schillaci, and Benedetta Maggio, and Livio Torta
Synthesis and antituberculosis activity of new N-phenyl-N'-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thioureas.
July 2002, Farmaco (Societa chimica italiana : 1989),
Demetrio Raffa, and Giuseppe Daidone, and Fabiana Plescia, and Domenico Schillaci, and Benedetta Maggio, and Livio Torta
N-(3-Chloro-1-methyl-1H-indazol-5-yl)-4-methylbenzene-sulfonamide.
February 2014, Acta crystallographica. Section E, Structure reports online,
Demetrio Raffa, and Giuseppe Daidone, and Fabiana Plescia, and Domenico Schillaci, and Benedetta Maggio, and Livio Torta
N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene] 2/4-substituted hydrazides: synthesis and anticonvulsant activity.
September 2010, European journal of medicinal chemistry,
Demetrio Raffa, and Giuseppe Daidone, and Fabiana Plescia, and Domenico Schillaci, and Benedetta Maggio, and Livio Torta
Synthesis, characterization and anti-inflammatory activity of N-(4- phenyl-1, 3-thiazol-2-yl)-N'-phenylureas.
January 2014, Anti-inflammatory & anti-allergy agents in medicinal chemistry,
Demetrio Raffa, and Giuseppe Daidone, and Fabiana Plescia, and Domenico Schillaci, and Benedetta Maggio, and Livio Torta
Synthesis and anticonvulsant activity of new N-phenyl-2-(4-phenylpiperazin-1-yl)acetamide derivatives.
January 2015, Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents,
Demetrio Raffa, and Giuseppe Daidone, and Fabiana Plescia, and Domenico Schillaci, and Benedetta Maggio, and Livio Torta
2-(2H-Indazol-2-yl)-1-phenyl-ethanone.
February 2013, Acta crystallographica. Section E, Structure reports online,
Demetrio Raffa, and Giuseppe Daidone, and Fabiana Plescia, and Domenico Schillaci, and Benedetta Maggio, and Livio Torta
Synthesis and antifungal activity of some new 3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl) chromones.
February 2008, European journal of medicinal chemistry,
Demetrio Raffa, and Giuseppe Daidone, and Fabiana Plescia, and Domenico Schillaci, and Benedetta Maggio, and Livio Torta
Synthesis and Leishmanicidal Activity of 1-[5-(5-Nitrofuran-2-yl)-1, 3, 4-Thiadiazole-2-yl]-4-BenzoylePiperazines.
January 2017, Iranian journal of pharmaceutical research : IJPR,
Demetrio Raffa, and Giuseppe Daidone, and Fabiana Plescia, and Domenico Schillaci, and Benedetta Maggio, and Livio Torta
[Synthesis and antimicrobial activity of N-[ 5-(3-pyridyl)-1, 3, 4-thiadiazol-2-yl] -N'-aroyl urea].
January 2007, Yao xue xue bao = Acta pharmaceutica Sinica,
Demetrio Raffa, and Giuseppe Daidone, and Fabiana Plescia, and Domenico Schillaci, and Benedetta Maggio, and Livio Torta
Synthesis of new derivatives of 1-(2-aminoethyl)-4-phenyl-3-(pyridin-3-yl)-1,2,4-triazoline-5-thione.
December 2004, Acta poloniae pharmaceutica,
Copied contents to your clipboard!