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A method has been devised to measure regional myocardial blood flow in man. The approach consists of selective injection of xenon-133 into a coronary artery and the external monitoring of radioisotope washout curves from multiple areas of the myocardium with a multiple crystal scintillation camera. Rate constants of isotope washout are calculated using a monoexponential model, and the capillary blood flow rates in multiple regions of the heart are calculated by the Kety formula. The pattern of perfusion rates is related to the coronary arteriogram obtained in the same study. Myocardial perfusion patterns obtained in patients with and without coronary artery disease and during atrial pacing are given, as well as examples of results obtained in myocardial aneurysms, in regions of ischemic myocardium supplied by collateral vessels and after tracer injection into an aortocoronary bypass graft. Advantages of the method are discussed along with limitations related to the tracer, the scintillation camera, the form of mathematical analysis and the three dimensional nature of the heart.
P J Cannon, and
R R Sciacca, and
D L Fowler, and
M B Weiss, and
D H Schmidt, and
W J Casarella
April 1972,
The Journal of clinical investigation,
P J Cannon, and
R R Sciacca, and
D L Fowler, and
M B Weiss, and
D H Schmidt, and
W J Casarella
January 1978,
Investigative radiology,
P J Cannon, and
R R Sciacca, and
D L Fowler, and
M B Weiss, and
D H Schmidt, and
W J Casarella
December 1969,
Radiology,
P J Cannon, and
R R Sciacca, and
D L Fowler, and
M B Weiss, and
D H Schmidt, and
W J Casarella
September 1979,
Clinical nuclear medicine,
P J Cannon, and
R R Sciacca, and
D L Fowler, and
M B Weiss, and
D H Schmidt, and
W J Casarella
January 1970,
The American journal of roentgenology, radium therapy, and nuclear medicine,
P J Cannon, and
R R Sciacca, and
D L Fowler, and
M B Weiss, and
D H Schmidt, and
W J Casarella
January 1981,
Advances in neurology,
P J Cannon, and
R R Sciacca, and
D L Fowler, and
M B Weiss, and
D H Schmidt, and
W J Casarella
October 1972,
Polskie Archiwum Medycyny Wewnetrznej,
P J Cannon, and
R R Sciacca, and
D L Fowler, and
M B Weiss, and
D H Schmidt, and
W J Casarella
March 1973,
Biomedical engineering,
P J Cannon, and
R R Sciacca, and
D L Fowler, and
M B Weiss, and
D H Schmidt, and
W J Casarella
January 1977,
International journal of neurology,
P J Cannon, and
R R Sciacca, and
D L Fowler, and
M B Weiss, and
D H Schmidt, and
W J Casarella
January 1975,
Recent advances in studies on cardiac structure and metabolism,
