Biomaterial Database

Effect of flow and vascular heterogeneity on glucose metabolism in isolated dog hearts. 2002

J T Kuikka

Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland. jkuikka@uku.fi

In non-ischaemic myocardium glucose uptake is assumed to be proportional to blood flow. We investigated the effect of regional vascular heterogeneity on glucose metabolism at various flow rates in the isolated blood-perfused dog hearts. Aortic bolus injections contained an intravascular reference tracer (albumin) and two of three glucoses: L-glucose (an extracellular tracer), D-glucose and 2-deoxy-D-glucose. Flow ranged from 0.5 to 2 4 ml min(-1) g(-1). Vascular heterogeneity was calculated from the albumin outflow dilution curve. A three-region convection-diffusion from the abumin outflow dilution curve. A three-region, convection-diffusion model was fitted to outflow dilution curves to estimate glucose metabolic rate (consumption). The results of 2-deoxy-D-glucose experiments showed that the lumped constant was dependent on flow, glucose metabolic rate was proportional to flow and dependent on the heterogeneity of the myocardial vasculature. The results support the views that without accounting the regional flow heterogeneity, glucose metabolic rate will be underestimated.

UI	MeSH Term	Description	Entries
D007457	Iodine Radioisotopes	Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.	Radioisotopes, Iodine
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D002250	Carbon Radioisotopes	Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.	Radioisotopes, Carbon
D003326	Coronary Circulation	The circulation of blood through the CORONARY VESSELS of the HEART.	Circulation, Coronary
D003847	Deoxyglucose	2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.	2-Deoxy-D-glucose,2-Deoxyglucose,2-Desoxy-D-glucose,2 Deoxy D glucose,2 Deoxyglucose,2 Desoxy D glucose
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005947	Glucose	A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.	Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D000418	Albumins	Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.	Albumin
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014316	Tritium	The radioactive isotope of hydrogen also known as hydrogen-3. It contains two NEUTRONS and one PROTON in its nucleus and decays to produce low energy BETA PARTICLES.	Hydrogen-3,Hydrogen 3