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The bronchodilator activity of AY-23 578 was studied in vivo and in vitro techniques. In the conscious guinea pig, aerosols of AY-23 578, prostaglandin (PGE2) E2, and isoproterenol afforded significant protection against histamine-induced convulsions. In the anesthetized guinea pig, where changes in tracheal pressure were taken as an index of bronchoconstriction, AY-23 578, PGE2, and isoproterenol were equipotent in inhibiting the bronchoconstriction induced by histamine. AY-23 578, PGE2, and isoproterenol reduced or prevented neostigmine-, prostaglandin F2alpha- or carbachol-induced increases in pulmonary resistance, and decreases in dynamic compliance in the anesthetized cat. The activities of the former two compounds were qualitatively similar but less potent than isoproterenol. In both the guinea pig and the cat, the aerosol administration of effective bronchodilator doses of AY-23 578 did not exhibit any significant cardiovascular effects. Both AY-23 578 and PGE2 caused relaxation of the isolated guinea pig tracheal strip; PGE2 was about six times more potent than AY-23 578. It is concluded that AY-23 578 is an effective bronchodilator in both the guinea pig and cat.
R Greenberg, and
K Smorong
January 1982,
Problemy endokrinologii,
R Greenberg, and
K Smorong
May 1974,
The Journal of urology,
R Greenberg, and
K Smorong
February 1974,
Canadian journal of physiology and pharmacology,
R Greenberg, and
K Smorong
August 1983,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
R Greenberg, and
K Smorong
January 1986,
Doklady Akademii nauk SSSR,
R Greenberg, and
K Smorong
May 1984,
Prostaglandins,
R Greenberg, and
K Smorong
January 2002,
Bioorganicheskaia khimiia,
R Greenberg, and
K Smorong
January 1984,
Problemy endokrinologii,
R Greenberg, and
K Smorong
January 1967,
Tetrahedron letters,
R Greenberg, and
K Smorong
August 1981,
Prostaglandins,
