Biomaterial Database

Plasma free amino acids in the chronically uremic rat. 1975

A Mannan, and L I Wiebe, and A A Noujaim, and D C Secord

Plasma free amino acids in the sub-totally nephrectomized chronic uremic rat have been quantitated. The concentrations of these substances in uremic rats have been compared to levels present in sham-operated controls, and to levels found in normal rats on a restricted diet. Phosphoserine, alpha-aminoadipic acid, 1-methylhistidine and 3-methylhistidine concentrations were found to be significantly higher in the uremic group. Sub-normal amounts of serine, valine, tryptophan, asparagine and anserine were present in the serum of the uremic animals. No changes were detected in serum amino acids which are ketogenic. Serum glutamic oxaloacetic transaminase activity was reduced in both uremic and restricted diet rats.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D002908	Chronic Disease	Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D000596	Amino Acids	Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.	Amino Acid,Acid, Amino,Acids, Amino
D000601	Amino Acids, Essential	Amino acids that are not synthesized by the human body in amounts sufficient to carry out physiological functions. They are obtained from dietary foodstuffs.	Essential Amino Acid,Essential Amino Acids,Acid, Essential Amino,Acids, Essential Amino,Amino Acid, Essential
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014511	Uremia	A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.	Uremias
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus