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Influences of fat on release of insulin, growth hormone and pancreatic enzyme secretion were studied in 35 metabolically healthy subjects. A fat solution containing 40 g of soy bean oil was administered, I.V., orally and intraduodenally. In all cases there was a similar increase of insulin but the rise in serum insulin after oral or intraduodenal fat administration was not related to the changes in plasma free fatty acids, free glycerol and triglyceride levels. Blood surgar responded according to insulin secretion. The route of fat administration may possibly influence growth hormone secretion. Following intraduodenal fat administration volume and bicarbonate contents of the duodenal juice rose slightly whereas trypsin and bilirubin content increased considerably. These results suggest that insulin secretion after oral or intraduodenal administration of fat is influenced by intestinal factors. Cholecystokinin-pancroezymin and gastric inhibitory polypeptide are qualified to serve as such factors.
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H C Dollinger, and
L von Berger, and
J Kissing, and
K E Schröder, and
U Klör, and
E F Pfeiffer
October 1977,
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S Raptis, and
H C Dollinger, and
L von Berger, and
J Kissing, and
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U Klör, and
E F Pfeiffer
January 1973,
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S Raptis, and
H C Dollinger, and
L von Berger, and
J Kissing, and
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E F Pfeiffer
July 1976,
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S Raptis, and
H C Dollinger, and
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K E Schröder, and
U Klör, and
E F Pfeiffer
August 1968,
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S Raptis, and
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J Kissing, and
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E F Pfeiffer
January 1981,
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S Raptis, and
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November 1989,
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S Raptis, and
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E F Pfeiffer
November 1982,
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S Raptis, and
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E F Pfeiffer
January 1958,
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S Raptis, and
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May 1986,
Fukuoka igaku zasshi = Hukuoka acta medica,
