Lactose intolerance. 2002

Daniel L Swagerty, and Anne D Walling, and Robert M Klein
Department of Family Medicine, University of Kansas School of Medicine, Kansas City 66160-7370, USA. dswagert@kumc.edu

Persons with lactose intolerance are unable to digest significant amounts of lactose because of a genetically inadequate amount of the enzyme lactase. Common symptoms include abdominal pain and bloating, excessive flatus, and watery stool following the ingestion of foods containing lactose. Lactase deficiency is present in up to 15 percent of persons of northern European descent, up to 80 percent of blacks and Latinos, and up to 100 percent of American Indians and Asians. A sizable number of adults believe they are lactose intolerant but do not actually have impaired lactose digestion, and some persons with lactase deficiency can tolerate moderate amounts of ingested lactose. A diagnosis of lactose intolerance can usually be made with a careful history supported by dietary manipulation. If necessary, diagnosis can be confirmed by using a breath hydrogen or lactose tolerance test. Treatment consists primarily of avoiding lactose-containing foods. Lactase enzyme supplements may be helpful. The degree of lactose malabsorption varies greatly among patients with lactose intolerance, but most of them can ingest up to 12 oz of milk daily without symptoms. Lactose-intolerant patients must ensure adequate calcium intake.

UI MeSH Term Description Entries
D007787 Lactose Intolerance The condition resulting from the absence or deficiency of LACTASE in the MUCOSA cells of the GASTROINTESTINAL TRACT, and the inability to break down LACTOSE in milk for ABSORPTION. Bacterial fermentation of the unabsorbed lactose leads to symptoms that range from a mild indigestion (DYSPEPSIA) to severe DIARRHEA. Lactose intolerance may be an inborn error or acquired. Lactose Malabsorption,Alactasia,Dairy Product Intolerance,Hypolactasia,Milk Sugar Intolerance,Intolerance, Lactose,Malabsorption, Lactose
D002136 Calcium, Dietary Calcium compounds in DIETARY SUPPLEMENTS or in food that supply the body with calcium. Dietary Calcium
D005194 Family Practice A medical specialty concerned with the provision of continuing, comprehensive primary health care for the entire family. Family Practices,Practice, Family,Practices, Family
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001616 beta-Galactosidase A group of enzymes that catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-galactosides. Deficiency of beta-Galactosidase A1 may cause GANGLIOSIDOSIS, GM1. Lactases,Dairyaid,Lactaid,Lactogest,Lactrase,beta-D-Galactosidase,beta-Galactosidase A1,beta-Galactosidase A2,beta-Galactosidase A3,beta-Galactosidases,lac Z Protein,Protein, lac Z,beta D Galactosidase,beta Galactosidase,beta Galactosidase A1,beta Galactosidase A2,beta Galactosidase A3,beta Galactosidases
D043322 Lactase An enzyme which catalyzes the hydrolysis of LACTOSE to D-GALACTOSE and D-GLUCOSE. Defects in the enzyme cause LACTOSE INTOLERANCE. Lactose Galactohydrolase,Galactohydrolase, Lactose

Related Publications

Daniel L Swagerty, and Anne D Walling, and Robert M Klein
November 1984, The Canadian nurse,
Daniel L Swagerty, and Anne D Walling, and Robert M Klein
January 1980, The New England journal of medicine,
Daniel L Swagerty, and Anne D Walling, and Robert M Klein
January 1980, The New England journal of medicine,
Daniel L Swagerty, and Anne D Walling, and Robert M Klein
July 1995, The New England journal of medicine,
Daniel L Swagerty, and Anne D Walling, and Robert M Klein
June 1985, Wiadomosci lekarskie (Warsaw, Poland : 1960),
Daniel L Swagerty, and Anne D Walling, and Robert M Klein
September 1991, Lancet (London, England),
Daniel L Swagerty, and Anne D Walling, and Robert M Klein
November 1991, Lancet (London, England),
Daniel L Swagerty, and Anne D Walling, and Robert M Klein
January 1994, Postgraduate medicine,
Daniel L Swagerty, and Anne D Walling, and Robert M Klein
November 1995, The New England journal of medicine,
Daniel L Swagerty, and Anne D Walling, and Robert M Klein
May 1977, The American journal of nursing,
Copied contents to your clipboard!