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The effects of preexposure of rats to cobaltous chloride (CO) mixed in iron-sufficient (I.S) and -deficient (I.D) diets on hepatic microsomal electron transfer system was investigated. Male Sprague-Dawley rats were fed for 4 weeks on I.D diets mixed with 0, 100 and 200 ppm CO. At the end of 4 weeks three rats from each group were transferred to I.S diets mixed with the same amount of CO. Liver microsomal NADPH - Cytochrome C reductase, NADPH - dehydrogenase, cytochrome P-450 and aniline binding were determined in both batches of rats. The rats receiving CO in the I.D diets showed a 35, 60, 75 and 40% decrease in NADPH - Cyt. C reductase, dehydrogenase, Cyt. P-450 and aniline binding respectively. The rats transferred from I.D diet to I.S diet showed a complete recovery of the inhibition of the microsomal electron transfer system. The rats receiving 200 ppm mixed with I.S diets did not show any changes in any biochemical parameter measured.
K N Chetty, and
L Drummond, and
D S Subba Rao, and
D Desaiah
June 1982,
Biochemical pharmacology,
K N Chetty, and
L Drummond, and
D S Subba Rao, and
D Desaiah
October 1980,
Biochemical pharmacology,
K N Chetty, and
L Drummond, and
D S Subba Rao, and
D Desaiah
February 1977,
Biochemical and biophysical research communications,
K N Chetty, and
L Drummond, and
D S Subba Rao, and
D Desaiah
June 1987,
Journal of applied toxicology : JAT,
K N Chetty, and
L Drummond, and
D S Subba Rao, and
D Desaiah
January 1978,
Drug metabolism and disposition: the biological fate of chemicals,
K N Chetty, and
L Drummond, and
D S Subba Rao, and
D Desaiah
March 1992,
The Journal of pharmacology and experimental therapeutics,
K N Chetty, and
L Drummond, and
D S Subba Rao, and
D Desaiah
March 1981,
Biochemical pharmacology,
K N Chetty, and
L Drummond, and
D S Subba Rao, and
D Desaiah
March 1980,
Biochemical pharmacology,
K N Chetty, and
L Drummond, and
D S Subba Rao, and
D Desaiah
January 1984,
Annals of the New York Academy of Sciences,
K N Chetty, and
L Drummond, and
D S Subba Rao, and
D Desaiah
May 1977,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
