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The behavioural effects of increasing doses of apomorphine and haloperidol were observed in a group of six marmosets. Behaviour was classified quantitatively into categories: Locomotion, inactivity, checking (small head movements), social interaction and purposeful activities. Statistical analysis revealed that apomorphine had a stimulant effect on checking and locomotion which could be antagonized by haloperidol. Activities and social contact were severly reduced by both apomorphine and haloperidol. Inactivity was increased by the lowest dose of apomorphine in otherwise untreated animals. It is suggested that haloperidol antagonizes the stimulant effects of apomorphine but is synergistic to its suppressant effects, and that the low dose effect of apomorphine on inactivity is mediated by a mechanism which may be different from that acted upon by haloperidol.
P R Scraggs, and
H F Baker, and
R M Ridley
June 1978,
British journal of pharmacology,
P R Scraggs, and
H F Baker, and
R M Ridley
January 1985,
Psychopharmacology,
P R Scraggs, and
H F Baker, and
R M Ridley
December 1987,
Behavioural processes,
P R Scraggs, and
H F Baker, and
R M Ridley
November 1978,
Archives internationales de pharmacodynamie et de therapie,
P R Scraggs, and
H F Baker, and
R M Ridley
January 1983,
Voprosy onkologii,
P R Scraggs, and
H F Baker, and
R M Ridley
August 1984,
Neuropharmacology,
P R Scraggs, and
H F Baker, and
R M Ridley
October 1989,
Pharmacology, biochemistry, and behavior,
P R Scraggs, and
H F Baker, and
R M Ridley
January 1988,
Zeitschrift fur Naturforschung. C, Journal of biosciences,
P R Scraggs, and
H F Baker, and
R M Ridley
October 1982,
Biochemical pharmacology,
P R Scraggs, and
H F Baker, and
R M Ridley
August 1986,
The Journal of physiology,
