The evaluation and management of enuresis has long been a common and challenging problem in everyday practice. Enuresis is a symptom believed to result from a variety of etiological factors, including genitourinary disease, neurological disturbances, delayed development, allergic reactions, deep sleep, and psychological factors. Although enuresis is frequently a self-limiting condition, every child presenting with this problem deserves a careful work-up and consideration of therapy based on the probable underlying cause. There are five major approaches to therapy of enuresis: psychological, psycho-physiological, medication (particularly imipramine HC1), conditioning therapy, and dietary restrictions. Effective therapy will often involve more than one approach and should be tailored on an individual basis to meet each child's particular needs.