[Hereditary recurrent epistaxis]. 1975

T Mikhaylov

The author has carried out a clinical and genetic investigation of a large family who lives in the south of the Algerian Sahara and comprises 213 individuals belonging to 8 generations. Among the examined members of this family, 105 (49.2%) showed repeated nose bleeding. However, no anomalies of the blood or the coagulation could be found in these patients. From the physical point of view they were all normally developed and vigorous. The distribution of the patients according to age showed no pedilection for any age group (affected individuals between 7 months and 85 years). The condition affected both sexes with a slight predominance in favour of females (53.4% of women against 46.6% of men). The inheritance is autosomal dominant wigh sometimes skipping of one or several generations. In one sibship all 13 members were affected owing to the fact that the father was an affected homozygote, offspring of a marriage between two affected cousins. The author proposes for this new noslological and genetic entity the term hereditary recurrent epistaxis. This capillaropathy has to be distinguished in particular from hereditary hemorrhagic telangiectasia of Rendu-Osler.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010375 Pedigree The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition. Family Tree,Genealogical Tree,Genealogic Tree,Genetic Identity,Identity, Genetic,Family Trees,Genealogic Trees,Genealogical Trees,Genetic Identities,Identities, Genetic,Tree, Family,Tree, Genealogic,Tree, Genealogical,Trees, Family,Trees, Genealogic,Trees, Genealogical
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D012008 Recurrence The return of a sign, symptom, or disease after a remission. Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D003937 Diagnosis, Differential Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures. Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D004844 Epistaxis Bleeding from the nose. Nose Bleed,Nosebleed,Nasal Bleeding,Nosebleeds,Bleeding, Nasal,Bleedings, Nasal,Nasal Bleedings,Nose Bleeds

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