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We produced experimental atrophic gastritis in 7 mongrel dogs by explanting a full-thickness wedge of vascularized mucosa from the gastric greater curvature onto the abdominal wall. Autoradiography of mucosal specimens was done after the iv injection of triated thymidine. The labeling index, S-phase duration, and cell cycle time were measured in normal and explanted fundic mucosa. The spatial distribution histograms of the labeled cells showed an enlarged are of proliferation. As in human atrophic gastritis, proliferation was shifted toward the mucosal surface. Significantly higher labeling indices were observed in the atrophic mucosa. Shortening of the S-phase duration and the cell cycle time was indicated by the curves of the labeled mitoses. Proliferative activity was significantly accelerated in this experimental model of atrophic gastritis.
P P Casteleyn, and
G Willems
January 1970,
Folia allergologica,
P P Casteleyn, and
G Willems
January 1970,
Archives francaises des maladies de l'appareil digestif,
P P Casteleyn, and
G Willems
July 1980,
Klinicheskaia meditsina,
P P Casteleyn, and
G Willems
November 2007,
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine,
P P Casteleyn, and
G Willems
April 1990,
Hepato-gastroenterology,
P P Casteleyn, and
G Willems
August 1951,
American practitioner and digest of treatment,
P P Casteleyn, and
G Willems
October 1968,
Surgery,
P P Casteleyn, and
G Willems
January 1981,
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi,
P P Casteleyn, and
G Willems
November 1964,
Deutsches Archiv fur klinische Medizin,
P P Casteleyn, and
G Willems
January 1968,
Digestion,
