-transparent.png){kind=logo}
Continuous control of the pressure of spontaneously hypertensive rats at systolic levels of 90-100 mm Hg with antihypertensive agents significantly prolonged their life span. The mean survival time in control animals was 73 weeks as compared to 96 weeks in treated SHR (P less than .0005) with 11% of the latter surviving to approximately 3 yr of age. Cardiovascular lesions were limited almost exclusively to the control rats. The general health, body weight and reproductive functions of the experimental animals remained normal throughout the drug treatment. These results indicate that by preventing the rise in blood pressure and consequent cardiovascular complications the life span of the SHR may be prolonged to that of the normal albino rat.
E D Freis, and
D Ragan
January 1995,
Gerontology,
E D Freis, and
D Ragan
January 1981,
Experimental gerontology,
E D Freis, and
D Ragan
January 2001,
Clinical and experimental hypertension (New York, N.Y. : 1993),
E D Freis, and
D Ragan
December 1976,
Clinical science and molecular medicine. Supplement,
E D Freis, and
D Ragan
January 2013,
Biomedical reports,
E D Freis, and
D Ragan
January 1991,
Hypertension (Dallas, Tex. : 1979),
E D Freis, and
D Ragan
July 1994,
Clinical and experimental hypertension (New York, N.Y. : 1993),
E D Freis, and
D Ragan
December 1995,
Clinical and experimental pharmacology & physiology. Supplement,
E D Freis, and
D Ragan
July 1971,
Japanese circulation journal,
E D Freis, and
D Ragan
December 1986,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
