Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. 2002

Takaharu Okada, and Vu N Ngo, and Eric H Ekland, and Reinhold Förster, and Martin Lipp, and Dan R Littman, and Jason G Cyster
Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA.

B cell entry to lymph nodes and Peyer's patches depends on chemokine receptor signaling, but the principal chemokine involved has not been defined. Here we show that the homing of CXCR4-/- B cells is suppressed in CCL19 (ELC)- and CCL21 (SLC)-deficient paucity of lymph node T cells mice, but not in wild-type mice. We also find that CXCR4 can contribute to T cell homing. Using intravital microscopy, we find that B cell adhesion to high endothelial venules (HEVs) is disrupted when CCR7 and CXCR4 are predesensitized. In Peyer's patches, B cell entry is dependent on CXCR5 in addition to CCR7/CXCR4. CXCL12 (SDF1) is displayed broadly on HEVs, whereas CXCL13 (BLC) is found selectively on Peyer's patch follicular HEVs. These findings establish the principal chemokine and chemokine receptor requirements for B cell entry to lymph nodes and Peyer's patches.

UI MeSH Term Description Entries
D008198 Lymph Nodes They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. Lymph Node,Node, Lymph,Nodes, Lymph
D008815 Mice, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D008817 Mice, Mutant Strains Mice bearing mutant genes which are phenotypically expressed in the animals. Mouse, Mutant Strain,Mutant Mouse Strain,Mutant Strain of Mouse,Mutant Strains of Mice,Mice Mutant Strain,Mice Mutant Strains,Mouse Mutant Strain,Mouse Mutant Strains,Mouse Strain, Mutant,Mouse Strains, Mutant,Mutant Mouse Strains,Mutant Strain Mouse,Mutant Strains Mice,Strain Mouse, Mutant,Strain, Mutant Mouse,Strains Mice, Mutant,Strains, Mutant Mouse
D010581 Peyer's Patches Lymphoid tissue on the mucosa of the small intestine. Patches, Peyer's,Peyer Patches,Peyers Patches
D002448 Cell Adhesion Adherence of cells to surfaces or to other cells. Adhesion, Cell,Adhesions, Cell,Cell Adhesions
D002465 Cell Movement The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell. Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell
D004730 Endothelium, Vascular Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components. Capillary Endothelium,Vascular Endothelium,Capillary Endotheliums,Endothelium, Capillary,Endotheliums, Capillary,Endotheliums, Vascular,Vascular Endotheliums
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001402 B-Lymphocytes Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. B-Cells, Lymphocyte,B-Lymphocyte,Bursa-Dependent Lymphocytes,B Cells, Lymphocyte,B Lymphocyte,B Lymphocytes,B-Cell, Lymphocyte,Bursa Dependent Lymphocytes,Bursa-Dependent Lymphocyte,Lymphocyte B-Cell,Lymphocyte B-Cells,Lymphocyte, Bursa-Dependent,Lymphocytes, Bursa-Dependent
D012333 RNA, Messenger RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. Messenger RNA,Messenger RNA, Polyadenylated,Poly(A) Tail,Poly(A)+ RNA,Poly(A)+ mRNA,RNA, Messenger, Polyadenylated,RNA, Polyadenylated,mRNA,mRNA, Non-Polyadenylated,mRNA, Polyadenylated,Non-Polyadenylated mRNA,Poly(A) RNA,Polyadenylated mRNA,Non Polyadenylated mRNA,Polyadenylated Messenger RNA,Polyadenylated RNA,RNA, Polyadenylated Messenger,mRNA, Non Polyadenylated

Related Publications

Takaharu Okada, and Vu N Ngo, and Eric H Ekland, and Reinhold Förster, and Martin Lipp, and Dan R Littman, and Jason G Cyster
February 2009, Journal of immunology (Baltimore, Md. : 1950),
Takaharu Okada, and Vu N Ngo, and Eric H Ekland, and Reinhold Förster, and Martin Lipp, and Dan R Littman, and Jason G Cyster
June 2008, Seminars in immunology,
Takaharu Okada, and Vu N Ngo, and Eric H Ekland, and Reinhold Förster, and Martin Lipp, and Dan R Littman, and Jason G Cyster
November 1991, Cellular immunology,
Takaharu Okada, and Vu N Ngo, and Eric H Ekland, and Reinhold Förster, and Martin Lipp, and Dan R Littman, and Jason G Cyster
August 2003, Journal of immunology (Baltimore, Md. : 1950),
Takaharu Okada, and Vu N Ngo, and Eric H Ekland, and Reinhold Förster, and Martin Lipp, and Dan R Littman, and Jason G Cyster
January 1988, Regional immunology,
Takaharu Okada, and Vu N Ngo, and Eric H Ekland, and Reinhold Förster, and Martin Lipp, and Dan R Littman, and Jason G Cyster
January 1988, Regional immunology,
Takaharu Okada, and Vu N Ngo, and Eric H Ekland, and Reinhold Förster, and Martin Lipp, and Dan R Littman, and Jason G Cyster
August 1997, Journal of immunology (Baltimore, Md. : 1950),
Takaharu Okada, and Vu N Ngo, and Eric H Ekland, and Reinhold Förster, and Martin Lipp, and Dan R Littman, and Jason G Cyster
June 2013, The Journal of experimental medicine,
Takaharu Okada, and Vu N Ngo, and Eric H Ekland, and Reinhold Förster, and Martin Lipp, and Dan R Littman, and Jason G Cyster
March 2009, Veterinary pathology,
Takaharu Okada, and Vu N Ngo, and Eric H Ekland, and Reinhold Förster, and Martin Lipp, and Dan R Littman, and Jason G Cyster
January 2005, Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
Copied contents to your clipboard!