-transparent.png){kind=logo}
Quantitative studies of the effects of defibrination (with ancrod) have been undertaken in two forms of allergic glomerular damage, nephrotoxic serum nephritis and acute serum sickness in rabbits. No differences in intrarenal fixation of nephrotoxic antibody, complement activation or host antibody response were detected between defibrinated and untreated rabbits with nephrotoxic serum nephritis. Defibrination prevented intraglomerular fibrin deposition in this disease; but some glomerular damage as shown by a rise in blood urea and endothelial proliferation still occurred in defibrinated animals. No differences in immune elimination of BSA, circulating immune complex formation or intrarenal localization of immune complexes were noted in defibrinated animals with acute serum sickness. No intraglomerular fibrin deposition was detected in treated or untreated animals in this disease model. It is concluded that the protective effects of ancrod are directly related to defibrination, and not to any other modification of allergic events.
P F Naish, and
D J Evans, and
D K Peters
January 1974,
Deutsche medizinische Wochenschrift (1946),
P F Naish, and
D J Evans, and
D K Peters
November 1973,
Deutsche medizinische Wochenschrift (1946),
P F Naish, and
D J Evans, and
D K Peters
November 1976,
Thrombosis and haemostasis,
P F Naish, and
D J Evans, and
D K Peters
January 1971,
Folia haematologica (Leipzig, Germany : 1928),
P F Naish, and
D J Evans, and
D K Peters
November 1976,
Kidney international,
P F Naish, and
D J Evans, and
D K Peters
February 1991,
The Journal of pharmacology and experimental therapeutics,
P F Naish, and
D J Evans, and
D K Peters
February 1971,
The Journal of pathology,
P F Naish, and
D J Evans, and
D K Peters
January 1972,
Cardiovascular research,
P F Naish, and
D J Evans, and
D K Peters
January 1982,
American journal of nephrology,
P F Naish, and
D J Evans, and
D K Peters
June 1983,
Transplantation,
