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Cloning of Glial Cell Line-derived Neurotrophic Factor Gene and Its Expression in Eukaryotic Cells. 1999
Qiong Jiang, and
Jian Liu, and
Kai Ge, and
Wei-Cheng Liu, and
Lan-Ying Sun, and
Xin-Yuan Liu, and
Zhong-Cheng Zheng
Shanghai Institute of Biochemistry the Chinese Academy of Science Shanghai 200031 China. sib203@sunm.shcnc.ac.cn
Glial cell line-derived neurotrophic factor gene (gdnf) was obtained by RT-PCR method. Its pro-duct in COS7 cells showed neurotrophic and protective effect on the dopaminergic neurons. Then gdnf gene was cloned into retrovirus vector pLNCX and packaged with PA317. Infectious particles thus obtained were used to infect rat myoblast cell line L-6TG. A cell clone L-6TG/gdnf was obtained after G418 selection. It will be applied to the ex vivo gene therapy study of Parkinson's disease.
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