Biomaterial Database

[Studies on cerebrospinal fluid diffusion of trimethoprim in children]. 1975

N Fries, and U Keuth, and J S Braun

Full quantitative fluorometric analysis of TMP in serum and cerebrospinal fluid in 91 infants and children (all anyhow designed for lumbar puncture for other reasons) 1/2 - 12 hours after i. v. injection of TMP in a single dose of 4 mg/kg (73 cases, tab. 1-2, fig. 1) or 12 mg/kg (18 cases, tab. 3, fig. 2). TMP in serum and cerebrospinal fluid showed regularly high plateaus for the whole time investigated, i.e. 12 hours after i. v. injection (fig. 1-2). The c.s.f./serum ratio for TMP (2-12 hours after injection) was 30-40%(fig. 1). After a dose of 12 mg/kg the ratio was even 50% and more (fig. 2). There were - in our material - no differences of the ratio according to c.s.f. state (normal - tab. 1, or pathological-tab. 2), or age. Considerating published data on enteral resorption of trimethoprim-sulfamethoxazole and c.s.f. diffussion of SMZ together with our results, we can expect a very intensifying proportion TMP: SMZ near 1:10 in cerebrospinal fluid after intake of officinal TMP-SMZ (Co-trimoxazol). This might have diagnostic and therapeutic consequences.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008581	Meningitis	Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)	Pachymeningitis,Meningitides,Pachymeningitides
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D004338	Drug Combinations	Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.	Drug Combination,Combination, Drug,Combinations, Drug
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013420	Sulfamethoxazole	A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)	Sulfamethylisoxazole,Gantanol,Sulfisomezole,Sulphamethoxazole
D014295	Trimethoprim	A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.	Proloprim,Trimpex