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A mixture of 2-3H and 4-14C-mestranol was administered orally to five women and 2-3H-mestranol alone to one woman. Reactions involving position 2 were extensive as judged by liberation of 3H into body water (14-45% of the dose). 17alpha-Ethynylestradiol, 2-hydroxy-17alpha-ethynylestradiol, 2-methoxy-17alpha-ethynylestradiol, 2-hydroxy-17alpha-ethynylestradiol 3-methyl ether and 16geta-hydroxy-17alpha-ethynylestradiol were measured in the "glucuronide" and pH1 fractions and mestranol, D-homoestrone-17a and D-homoestradiol-17abeta were also measured in the "glucuronide" fraction frum the urine to two of the women by reverse isotope dilution. Radioactive 2-methoxyestradiol accounted for less than 0.011% of the 14C dose in the "glucuronide" fraction of one of the women, consistent with the extent of de-ethynylation previously reported (Steroids, 25, 343 (1975).
J G Williams, and
K I Williams
January 1972,
Xenobiotica; the fate of foreign compounds in biological systems,
J G Williams, and
K I Williams
December 1973,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
J G Williams, and
K I Williams
December 1974,
Steroids,
J G Williams, and
K I Williams
March 1973,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
J G Williams, and
K I Williams
January 1979,
Pharmacology,
J G Williams, and
K I Williams
January 1968,
Journal of pharmaceutical sciences,
J G Williams, and
K I Williams
January 1970,
Chemical & pharmaceutical bulletin,
J G Williams, and
K I Williams
August 1969,
Acta endocrinologica,
J G Williams, and
K I Williams
February 1973,
The Journal of clinical endocrinology and metabolism,
J G Williams, and
K I Williams
January 1970,
Chemical & pharmaceutical bulletin,
