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BACKGROUND Several cross-reacting proteins have been identified as responsible of the co-occurrence of pollinosis and plant-derived food allergy. This association has been mainly described in the birch-apple syndrome but other pollens such as Olea europaea and other fruits may also contain homologous proteins. OBJECTIVE To evaluate the associations between sensitization to allergens of Olea europaea pollen and confirmed plant-derived food allergy, in addition to investigate if any pattern of clinical hypersensitivity of food allergy reaction (oral allergy syndrome (OAS) or anaphylaxis) and/or any fresh fruit or nut allergy, are associated to one or several Olea pollen allergen(s). METHODS One-hundred and thirty-four consecutive patients diagnosed with pollinosis by Olea were studied. Of these patients only 40, reported adverse reaction to plant-derived food. Twenty-one (group A) were classified as OAS and 19 (group B) as anaphylaxis. Skin-tests with six Olea pollen allergens and several groups of fruits, were performed. Double-blind placebo-controlled food challenge (DBPCFC), confirmed the diagnostics of food allergy with the exception of patients who suffered previous anaphylactic reaction. RESULTS All patients, showed a positive skin prick test (SPT), against one or more of Olea europaea allergens. Sensitization to Ole e 7, was more frequent (P = 0.02) in patients from group B. A total of 84 DBPCFC were performed with 44% positive results. Challenge confirmed at least the 50% of positive SPT in any case (peach: 68.42%; pear: 50%; melon: 71.42% and kiwi: 53.84%). In patients from group B, significant association with O. europaea pollen allergens were found between positive SPT to Rosaceae fruits and Ole e 3 (P = 0.045) and Ole e 7 (P = 0.03); Cucurbitaceae and Ole e 7 (P = 0.03) and Actinidiaceae with Ole e 3 (P = 0.04). CONCLUSIONS The results of this study, establish a new spectrum of associations between pollens and plant-derived foods: sensitization to olive profilin (Ole e 2) is not more frequent in OAS patients. Patients with anaphylactic reaction after eating fruit are also sensitized to Ole e 7, a LTP present in Olea pollen, and suffer pollinic symptoms. Finally a polcalcin (Ole e 3) could be also associated to Olea pollen respiratory and food allergy.
J F Florido Lopez, and
J Quiralte Enriquez, and
J M Arias de Saavedra Alías, and
B Saenz de San Pedro, and
E Martin Casañez
January 2002,
Allergy,
J F Florido Lopez, and
J Quiralte Enriquez, and
J M Arias de Saavedra Alías, and
B Saenz de San Pedro, and
E Martin Casañez
September 1993,
European journal of biochemistry,
J F Florido Lopez, and
J Quiralte Enriquez, and
J M Arias de Saavedra Alías, and
B Saenz de San Pedro, and
E Martin Casañez
January 2007,
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
J F Florido Lopez, and
J Quiralte Enriquez, and
J M Arias de Saavedra Alías, and
B Saenz de San Pedro, and
E Martin Casañez
May 2005,
International archives of allergy and immunology,
J F Florido Lopez, and
J Quiralte Enriquez, and
J M Arias de Saavedra Alías, and
B Saenz de San Pedro, and
E Martin Casañez
January 2002,
Allergy,
J F Florido Lopez, and
J Quiralte Enriquez, and
J M Arias de Saavedra Alías, and
B Saenz de San Pedro, and
E Martin Casañez
December 2016,
International journal of biometeorology,
J F Florido Lopez, and
J Quiralte Enriquez, and
J M Arias de Saavedra Alías, and
B Saenz de San Pedro, and
E Martin Casañez
September 2004,
Plant & cell physiology,
J F Florido Lopez, and
J Quiralte Enriquez, and
J M Arias de Saavedra Alías, and
B Saenz de San Pedro, and
E Martin Casañez
December 2015,
Biochimica et biophysica acta,
J F Florido Lopez, and
J Quiralte Enriquez, and
J M Arias de Saavedra Alías, and
B Saenz de San Pedro, and
E Martin Casañez
April 1993,
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
J F Florido Lopez, and
J Quiralte Enriquez, and
J M Arias de Saavedra Alías, and
B Saenz de San Pedro, and
E Martin Casañez
May 1993,
Allergy,
