Bacillus megaterium resistance to cloxacillin accompanied by a compensatory change in penicillin binding proteins.
1979
A F Giles, and
R E Reynolds
UI
MeSH Term
Description
Entries
D009154
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Mutations
D010403
Penicillin Resistance
Nonsusceptibility of an organism to the action of penicillins.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Plasma Protein Binding Capacity,Binding, Protein
D003023
Cloxacillin
A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.