This study assessed knowledge levels of health risks of tobacco use among the Asian American (AA) community in the Delaware Valley region of Pennsylvania and New Jersey, including metropolitan Philadelphia. A cross-sectional self-report survey was conducted to collect the information, and a stratified-cluster proportional sampling technique was used to obtain a representative sample size of the target population of Chinese, Korean, Vietnamese, and Cambodians. 1374 AA were recruited from 26 randomly selected community organization clusters; of the total recruited, 1174 completed the survey, which consisted of 410 Chinese, 436 Korean, 196 Vietnamese, 100 Cambodian and 32 other-group. Other-group was excluded for this study. Ten questions were asked to determine the knowledge level of the sample population. Results indicated that the vast majority of respondents (82.2%) recognized the association between smoking and increased risk of developing various types of cancers and heart disease. Between 81.3% and 93.3% of respondents recognized the increased risk for lung, mouth, throat.and esophageal cancer and heart disease. For these variables, there were statistically significant differences between the ethnic groups: Koreans were the most knowledgeable, followed by Chinese, Vietnamese, and Cambodians. For bladder, pancreatic, cervical, and kidney cancers, the percentage of respondents indicating an association between these cancers and smoking ranged from 49.2 to 56.8. There were no statistically significant differences among the four ethnic groups for these variables. Generally, however, results showed that the awareness level was higher among women and the more educated respondents, non-smokers and former smokers, and Chinese and Korean groups.