Biomaterial Database

Hormone replacement therapy with tibolone: effects on sexual functioning in postmenopausal women. 2002

Christian Egarter, and AtaM Topcuoglu, and Sonja Vogl, and Michael Sator

Department of Obstetrics and Gynecology, University of Vienna, Vienna, Austria. christian.egarter@akh-wien.ac.at

OBJECTIVE Because hormonal changes in postmenopausal women may be accompanied by sexual problems and a worsening of various aspects of libido, the aim of this study was to assess the effect of tibolone (Liviel(R)) on sexual life. METHODS Postmenopausal first-time users of hormone replacement therapy (HRT) were included in this open, multicenter study. Patients were treated with tibolone 2.5 mg daily for at least 4 months. Both at baseline and after 4 months of treatment, patients were asked to complete two different questionnaires rating the women's subjective assessment of their sexual problems or desires. RESULTS One hundred and eighty-four women were enrolled to receive HRT with tibolone. Overall, a significant increase in women's satisfaction with their sexual lives and a significant improvement in different aspects of libido was found. CONCLUSIONS Tibolone has beneficial effects on several aspects of sexual life in postmenopausal women. These effects may be due to both an increase in genital blood flow and the central estrogenic/androgenic activity.

UI	MeSH Term	Description	Entries
D007989	Libido	The psychic drive or energy associated with sexual instinct in the broad sense (pleasure and love-object seeking). It may also connote the psychic energy associated with instincts in general that motivate behavior.	Decreased Libido,Increased Libido,Libido, Decreased,Libido, Increased
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009652	Norpregnenes	Pregnenes with one double bond or more than three double bonds which have undergone ring contractions or are lacking carbon-18 or carbon-19..
D011795	Surveys and Questionnaires	Collections of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions.	Community Survey,Nonrespondent,Questionnaire,Questionnaires,Respondent,Survey,Survey Method,Survey Methods,Surveys,Baseline Survey,Community Surveys,Methodology, Survey,Nonrespondents,Questionnaire Design,Randomized Response Technique,Repeated Rounds of Survey,Respondents,Survey Methodology,Baseline Surveys,Design, Questionnaire,Designs, Questionnaire,Methods, Survey,Questionnaire Designs,Questionnaires and Surveys,Randomized Response Techniques,Response Technique, Randomized,Response Techniques, Randomized,Survey, Baseline,Survey, Community,Surveys, Baseline,Surveys, Community,Techniques, Randomized Response
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D017698	Postmenopause	The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.	Post-Menopause,Post-menopausal Period,Postmenopausal Period,Period, Post-menopausal,Period, Postmenopausal,Post Menopause,Post menopausal Period,Post-Menopauses
D020249	Hormone Replacement Therapy	Therapeutic use of hormones to alleviate the effects of hormone deficiency.	Replacement Therapy, Hormone,Therapy, Hormone Replacement,Hormone Replacement Therapies,Replacement Therapies, Hormone,Therapies, Hormone Replacement
D020847	Estrogen Receptor Modulators	Substances that possess antiestrogenic actions but can also produce estrogenic effects as well. They act as complete or partial agonist or as antagonist. They can be either steroidal or nonsteroidal in structure.	Antiestrogens,Antiestrogen,Estrogen Receptor Modulator,Modulator, Estrogen Receptor,Modulators, Estrogen Receptor,Receptor Modulator, Estrogen,Receptor Modulators, Estrogen