Monte Carlo simulation of DNA damage by low LET radiation using inhomogeneous higher order DNA targets. 2002

Ph Bernhardt, and W Friedland, and R Meckbach, and P Jacob, and H G Paretzke
GSF-National Research Center for Environment and Health, Institute of Radiation Protection, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany. bernhardt@gsf.de

To test possible effects of the heterogeneous nature of the cell nucleus on simulation results of radiation-induced DNA damage, inhomogeneous targets have been implemented in the biophysical code PARTRAC. The geometry of the DNA and the histones was defined by spheres around the constituent atoms. Electron cross sections in liquid water were scaled according to the mass density of the different materials, whereas photon cross sections were derived from the sum of the cross sections for the constituent atoms. In the case of higher energy electrons the simulations show an increase of energy deposition in the DNA proportional to its high mass density. For photons with energies in the range of the carbon and the oxygen K-shell (0.28-0.53 keV), cross sections of DNA are larger than those of water, leading to an increased yield of strand breaks per average absorbed dose in the cell nucleus.

UI MeSH Term Description Entries
D009010 Monte Carlo Method In statistics, a technique for numerically approximating the solution of a mathematical problem by studying the distribution of some random variable, often generated by a computer. The name alludes to the randomness characteristic of the games of chance played at the gambling casinos in Monte Carlo. (From Random House Unabridged Dictionary, 2d ed, 1993) Method, Monte Carlo
D003198 Computer Simulation Computer-based representation of physical systems and phenomena such as chemical processes. Computational Modeling,Computational Modelling,Computer Models,In silico Modeling,In silico Models,In silico Simulation,Models, Computer,Computerized Models,Computer Model,Computer Simulations,Computerized Model,In silico Model,Model, Computer,Model, Computerized,Model, In silico,Modeling, Computational,Modeling, In silico,Modelling, Computational,Simulation, Computer,Simulation, In silico,Simulations, Computer
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D004249 DNA Damage Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS. DNA Injury,DNA Lesion,DNA Lesions,Genotoxic Stress,Stress, Genotoxic,Injury, DNA,DNA Injuries
D004307 Dose-Response Relationship, Radiation The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation. Dose Response Relationship, Radiation,Dose-Response Relationships, Radiation,Radiation Dose-Response Relationship,Radiation Dose-Response Relationships,Relationship, Radiation Dose-Response,Relationships, Radiation Dose-Response
D018499 Linear Energy Transfer Rate of energy dissipation along the path of charged particles. In radiobiology and health physics, exposure is measured in kiloelectron volts per micrometer of tissue (keV/micrometer T). Energy Transfer, Linear,LET,Transfer, Linear Energy

Related Publications

Ph Bernhardt, and W Friedland, and R Meckbach, and P Jacob, and H G Paretzke
August 1998, Radiation research,
Ph Bernhardt, and W Friedland, and R Meckbach, and P Jacob, and H G Paretzke
December 1994, International journal of radiation biology,
Ph Bernhardt, and W Friedland, and R Meckbach, and P Jacob, and H G Paretzke
January 1994, Basic life sciences,
Ph Bernhardt, and W Friedland, and R Meckbach, and P Jacob, and H G Paretzke
September 2018, Radiation research,
Ph Bernhardt, and W Friedland, and R Meckbach, and P Jacob, and H G Paretzke
June 2017, Australasian physical & engineering sciences in medicine,
Ph Bernhardt, and W Friedland, and R Meckbach, and P Jacob, and H G Paretzke
November 2020, Scientific reports,
Ph Bernhardt, and W Friedland, and R Meckbach, and P Jacob, and H G Paretzke
October 2005, Physical chemistry chemical physics : PCCP,
Ph Bernhardt, and W Friedland, and R Meckbach, and P Jacob, and H G Paretzke
July 1989, Physical review letters,
Ph Bernhardt, and W Friedland, and R Meckbach, and P Jacob, and H G Paretzke
June 2000, International journal of radiation biology,
Ph Bernhardt, and W Friedland, and R Meckbach, and P Jacob, and H G Paretzke
May 2014, International journal of radiation biology,
Copied contents to your clipboard!