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A liquid-phase peptide synthesis in cyclohexane-based biphasic thermomorphic systems. 2002

Kazuhiro Chiba, and Yusuke Kono, and Shokaku Kim, and Kohsuke Nishimoto, and Yoshikazu Kitano, and Masahiro Tada
Laboratory of Bio-Organic Chemistry, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan. chiba@cc.tuat.ac.jp

Combinations of typical organic solvents composed of cyclohexane and qualified aprotic polar organic solvents were found to realize an effective, biphasic thermomorphic system in arbitrary ratios of upper and lower phases that enable a practical application of a liquid-phase peptide synthesis.

UI MeSH Term Description Entries
D008722 Methods A series of steps taken in order to conduct research. Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D010455 Peptides Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS. Peptide,Polypeptide,Polypeptides
D003510 Cyclohexanes Six-carbon alicyclic hydrocarbons.
D005449 Fluorenes A family of diphenylenemethane derivatives.
D000596 Amino Acids Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins. Amino Acid,Acid, Amino,Acids, Amino
D012997 Solvents Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed) Solvent

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