Biomaterial Database

[Interaction of cimetidine and metoclopramide on the lower esophageal sphincter in man]. 1979

M Guelrud, and E Roa

The purpose of this study is to evaluate the effect of Cimetidine and Metoclopramide on human lower esophageal sphincter (LES) pressure. Intravenous Metoclopramide in a bolus injection (0.3 mg/Kg or a maximal dose of 20 mg) produced an increase of LES pressure from 20,8 +/- 3,1 mmHg to a peak response of 42,0 +/- 5,0 mmHg. Intravenous Cimetidine in a bolus injection of 300 mg failed to alter basal LES pressure and LES response to Metoclopramide. Cimetidine in continuous infusion (100 mg/h) also failed to alter basal LES pressure and LES response to intravenous Metoclopramide. These studies suggest that: (1) Human LES pressure increases in response to intravenous Metoclopramide; (2) H2-Antagonism with Cimetidine has no effect on the human LES basal pressure; and (3) The H-2 receptors have no apparent role in the human LES response to Metoclopramide.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008365	Manometry	Measurement of the pressure or tension of liquids or gases with a manometer.	Tonometry,Manometries
D008787	Metoclopramide	A dopamine D2 antagonist that is used as an antiemetic.	4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide,Cerucal,Maxolon,Metaclopramide,Metoclopramide Dihydrochloride,Metoclopramide Hydrochloride,Metoclopramide Monohydrochloride,Metoclopramide Monohydrochloride, Monohydrate,Primperan,Reglan,Rimetin,Dihydrochloride, Metoclopramide,Hydrochloride, Metoclopramide,Monohydrochloride, Metoclopramide
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009129	Muscle Tonus	The state of activity or tension of a muscle beyond that related to its physical properties, that is, its active resistance to stretch. In skeletal muscle, tonus is dependent upon efferent innervation. (Stedman, 25th ed)	Muscle Tension,Muscle Tightness,Muscular Tension,Tension, Muscle,Tension, Muscular,Tightness, Muscle,Tonus, Muscle
D002927	Cimetidine	A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.	Altramet,Biomet,Biomet400,Cimetidine HCl,Cimetidine Hydrochloride,Eureceptor,Histodil,N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine,SK&F-92334,SKF-92334,Tagamet,HCl, Cimetidine,Hydrochloride, Cimetidine,SK&F 92334,SK&F92334,SKF 92334,SKF92334
D004347	Drug Interactions	The action of a drug that may affect the activity, metabolism, or toxicity of another drug.	Drug Interaction,Interaction, Drug,Interactions, Drug
D004943	Esophagogastric Junction	The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.	Gastroesophageal Junction,Gastroesophageal Junctions,Junction, Esophagogastric,Junction, Gastroesophageal,Junctions, Gastroesophageal
D005260	Female		Females
D006146	Guanidines	A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.