-transparent.png){kind=logo}
Molecular defects in coagulation Factor VIII and their impact on Factor VIII function. 2002
E L Saenko, and
N Ananyeva, and
D Kouiavskaia, and
H Schwinn, and
D Josic, and
M Shima, and
C A E Hauser, and
S Pipe
J. Holland Laboratory, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA. saenko@usa.redcross.org
Molecular defects in Factor VIII (FVIII), such as haemophilia A-related mutations or denaturative conformational changes, may affect the stability of FVIII as well as its interactions with physiological activators, von Willebrand Factor, phospholipid, or conformationally sensitive antibodies. We summarize the contemporary assays which allow identification of impaired functional interactions of FVIII that cause a reduction or loss of its cofactor activity and/or increased immunogenicity. These assays can potentially be used for detection of molecular defects in FVIII and elucidation of the function impaired by these defects.
Related Publications
E L Saenko, and
N Ananyeva, and
D Kouiavskaia, and
H Schwinn, and
D Josic, and
M Shima, and
C A E Hauser, and
S Pipe
February 2021,
Blood advances,
E L Saenko, and
N Ananyeva, and
D Kouiavskaia, and
H Schwinn, and
D Josic, and
M Shima, and
C A E Hauser, and
S Pipe
January 1998,
Haemophilia : the official journal of the World Federation of Hemophilia,
E L Saenko, and
N Ananyeva, and
D Kouiavskaia, and
H Schwinn, and
D Josic, and
M Shima, and
C A E Hauser, and
S Pipe
July 1995,
Thrombosis and haemostasis,
E L Saenko, and
N Ananyeva, and
D Kouiavskaia, and
H Schwinn, and
D Josic, and
M Shima, and
C A E Hauser, and
S Pipe
January 2009,
Journal of molecular recognition : JMR,
E L Saenko, and
N Ananyeva, and
D Kouiavskaia, and
H Schwinn, and
D Josic, and
M Shima, and
C A E Hauser, and
S Pipe
March 1979,
Scandinavian journal of haematology,
E L Saenko, and
N Ananyeva, and
D Kouiavskaia, and
H Schwinn, and
D Josic, and
M Shima, and
C A E Hauser, and
S Pipe
June 2003,
International journal of pharmaceutics,
E L Saenko, and
N Ananyeva, and
D Kouiavskaia, and
H Schwinn, and
D Josic, and
M Shima, and
C A E Hauser, and
S Pipe
October 1998,
Ugeskrift for laeger,
E L Saenko, and
N Ananyeva, and
D Kouiavskaia, and
H Schwinn, and
D Josic, and
M Shima, and
C A E Hauser, and
S Pipe
January 2008,
Thrombosis research,
E L Saenko, and
N Ananyeva, and
D Kouiavskaia, and
H Schwinn, and
D Josic, and
M Shima, and
C A E Hauser, and
S Pipe
June 1988,
Lancet (London, England),
E L Saenko, and
N Ananyeva, and
D Kouiavskaia, and
H Schwinn, and
D Josic, and
M Shima, and
C A E Hauser, and
S Pipe
July 1988,
Lancet (London, England),
